Mapkap1 MAPK associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mapkap1provided by RGD
Full Name: MAPK associated protein 1provided by RGD
Primary source: RGD:1305363
See related: EnsemblRapid:ENSRNOG00000017583 AllianceGenome:RGD:1305363
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including enzyme binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Predicted to be involved in several processes, including TORC2 signaling; negative regulation of Ras protein signal transduction; and substantia nigra development. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be part of TORC2 complex. Predicted to be active in several cellular components, including endosome; lysosome; and mitochondrial outer membrane. Orthologous to human MAPKAP1 (MAPK associated protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 156.7), Thymus (RPKM 153.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (38113268..38315913)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (17715813..17918387)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (13484952..13701772)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH125848 (e-PCR)
- UniSTS:142645

RH143519 (e-PCR)
- UniSTS:232765

RH130453 (e-PCR)
- UniSTS:213737

d3rat192 (e-PCR)
- UniSTS:121837

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in substantia nigra development	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
NOT part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: target of rapamycin complex 2 subunit MAPKAP1

Names: SAPK-interacting protein 1; TORC2 subunit MAPKAP1; mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; stress-activated map kinase-interacting protein 1; target of rapamycin complex 2 subunit MAPKAP1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011964.1 → NP_001011964.1 target of rapamycin complex 2 subunit MAPKAP1

Status: PROVISIONAL

Source sequence(s)

BC079073

UniProtKB/Swiss-Prot

Q6AYF1

Related

ENSRNOP00000078499.2, ENSRNOT00000119554.2

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

38113268..38315913

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104765.2 → XP_038960693.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

Q6AYF1

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_063283509.1 → XP_063139579.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X2

UniProtKB/TrEMBL

A0A8I6AEY0
XM_063283505.1 → XP_063139575.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

Q6AYF1
XM_063283510.1 → XP_063139580.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X2

UniProtKB/TrEMBL

A0A8I6AEY0
XM_006233950.4 → XP_006234012.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

Q6AYF1

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_063283506.1 → XP_063139576.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

Q6AYF1
XM_006233949.4 → XP_006234011.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X1

UniProtKB/Swiss-Prot

Q6AYF1

Related

ENSRNOP00000102274.1, ENSRNOT00000139203.1

Conserved Domains (3) summary

cd13331
Location:383 → 490

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_063283508.1 → XP_063139578.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X2

UniProtKB/TrEMBL

A0A8I6AEY0

Related

ENSRNOP00000091071.1, ENSRNOT00000116389.2
XM_063283511.1 → XP_063139581.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X3

UniProtKB/TrEMBL

A0A8L2QCJ2

Related

ENSRNOP00000102771.1, ENSRNOT00000125836.1
XM_039104766.2 → XP_038960694.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X2

UniProtKB/TrEMBL

A0A8I6AEY0

Conserved Domains (3) summary

cd13331
Location:347 → 454

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam05422
Location:18 → 129

SIN1; Stress-activated map kinase interacting protein 1 (SIN1)

pfam16978
Location:140 → 266

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_039104768.2 → XP_038960696.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_008761721.3 → XP_008759943.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_008761722.3 → XP_008759944.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_017591656.3 → XP_017447145.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain
XM_017591654.3 → XP_017447143.1 target of rapamycin complex 2 subunit MAPKAP1 isoform X4

Conserved Domains (2) summary

cd13331
Location:191 → 298

PH_Avo1; Avo1 Pleckstrin homology (PH) domain

pfam16978
Location:1 → 74

CRIM; SAPK-interacting protein 1 (Sin1), middle CRIM domain