Nrarp Notch-regulated ankyrin repeat protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nrarpprovided by RGD
Official Full Name: Notch-regulated ankyrin repeat proteinprovided by RGD
Primary source: RGD:1591939
See related: EnsemblRapid:ENSRNOG00000009354 AllianceGenome:RGD:1591939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in angiogenesis; positive regulation of endothelial cell proliferation; and regulation of signal transduction. Predicted to act upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial cell proliferation; and somite rostral/caudal axis specification. Orthologous to human NRARP (NOTCH regulated ankyrin repeat protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28390745..28393299)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (7992582..7995136)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2396143..2398697)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-181b negatively regulated Nrarp as an anti-apoptotic gene via Notch signaling pathway in hippocampus.
Title: Mir-181b Functions as Anti-Apoptotic Gene in Post-Status Epilepticus via Modulation of Nrarp and Notch Signaling Pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:498750 (e-PCR)
- UniSTS:498750

Nrarp (e-PCR), detects polymorphism
- UniSTS:498750

RH133027 (e-PCR)
- UniSTS:216310

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloroplast targeting sequence binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to chloroplast	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somite rostral/caudal axis specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: notch-regulated ankyrin repeat-containing protein

Names: Maternal Effect Lethal family member (mel-11)-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.