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    Ficd FIC domain protein adenylyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288741, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ficdprovided by RGD
    Official Full Name
    FIC domain protein adenylyltransferaseprovided by RGD
    Primary source
    RGD:1359391
    See related
    EnsemblRapid:ENSRNOG00000059799 AllianceGenome:RGD:1359391
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including AMPylase activity; ATP binding activity; and Hsp70 protein binding activity. Predicted to be involved in several processes, including protein adenylylation; protein deadenylylation; and regulation of IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 44.5), Lung (RPKM 42.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ficd in Genome Data Viewer
    Location:
    12q16
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (48549737..48554626, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (42889195..42894090, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (48658283..48663175, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly enzyme Neighboring gene spliceosome associated factor 3, U4/U6 recycling protein Neighboring gene uncharacterized LOC120096010 Neighboring gene uncharacterized LOC120095862 Neighboring gene uncharacterized LOC120095863

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Bunney TD, et al. Structure, 2014 Dec 2. PMID 25435325, Free PMC Article
    2. A novel link between Fic (filamentation induced by cAMP)-mediated adenylylation/AMPylation and the unfolded protein response. Sanyal A, et al. J Biol Chem, 2015 Mar 27. PMID 25601083, Free PMC Article
    3. The fic domain: regulation of cell signaling by adenylylation. Worby CA, et al. Mol Cell, 2009 Apr 10. PMID 19362538, Free PMC Article
    4. Huntingtin interacts with a family of WW domain proteins. Faber PW, et al. Hum Mol Genet, 1998 Sep. PMID 9700202
    5. Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins. Engel P, et al. Nature, 2012 Jan 22. PMID 22266942

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables AMPylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMPylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables AMPylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables Hsp70 protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein adenylylhydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein adenylylhydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein adenylylhydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein adenylylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein adenylylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deadenylylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of IRE1-mediated unfolded protein response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of IRE1-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of IRE1-mediated unfolded protein response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to endoplasmic reticulum stress IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein adenylyltransferase FICD
    Names
    AMPylator FICD
    FIC domain containing
    FIC domain-containing protein
    adenosine monophosphate-protein transferase FICD
    de-AMPylase FICD
    huntingtin interactor protein E
    NP_001010946.1
    XP_008767542.1
    XP_008767543.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010946.1 → NP_001010946.1  protein adenylyltransferase FICD

      See identical proteins and their annotated locations for NP_001010946.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079197
      UniProtKB/Swiss-Prot
      Q6AY47
      UniProtKB/TrEMBL
      A0A8L2UR38, A6J228
      Conserved Domains (3) summary
      COG3177
      Location:227 → 411
      COG3177; Fic family protein [Transcription]
      TIGR02917
      Location:79 → 180
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:106 → 134
      TPR; TPR repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      48549737..48554626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008769321.4 → XP_008767543.1  protein adenylyltransferase FICD isoform X1

      See identical proteins and their annotated locations for XP_008767543.1

      UniProtKB/Swiss-Prot
      Q6AY47
      UniProtKB/TrEMBL
      A0A8L2UR38, A6J228
      Conserved Domains (3) summary
      COG3177
      Location:227 → 411
      COG3177; Fic family protein [Transcription]
      TIGR02917
      Location:79 → 180
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:106 → 134
      TPR; TPR repeat [structural motif]

    2. XM_008769320.4 → XP_008767542.1  protein adenylyltransferase FICD isoform X1

      See identical proteins and their annotated locations for XP_008767542.1

      UniProtKB/Swiss-Prot
      Q6AY47
      UniProtKB/TrEMBL
      A0A8L2UR38, A6J228
      Related
      ENSRNOP00000073778.2, ENSRNOT00000082809.3
      Conserved Domains (3) summary
      COG3177
      Location:227 → 411
      COG3177; Fic family protein [Transcription]
      TIGR02917
      Location:79 → 180
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:106 → 134
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AY47.1 GenPept UniProtKB/Swiss-Prot:Q6AY47

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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