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    Krt16 keratin 16 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303530, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Krt16provided by RGD
    Official Full Name
    keratin 16provided by RGD
    Primary source
    RGD:1590901
    See related
    EnsemblRapid:ENSRNOG00000003899 AllianceGenome:RGD:1590901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ka16; Krt14; Krt14l
    Summary
    Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in several processes, including establishment of skin barrier; keratinization; and keratinocyte migration. Predicted to act upstream of or within intermediate filament cytoskeleton organization. Predicted to be located in intermediate filament. Predicted to be active in cornified envelope. Biomarker of esophagus squamous cell carcinoma. Human ortholog(s) of this gene implicated in ectodermal dysplasia; focal nonepidermolytic palmoplantar keratoderma 1; and pachyonychia congenita. Orthologous to human KRT16 (keratin 16). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 21.7), Kidney (RPKM 6.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Krt16 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (85669276..85672211, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (85168357..85171816, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (88149210..88152167, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene keratin 14 Neighboring gene type I keratin KA11 Neighboring gene keratin 17 Neighboring gene keratin 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Forced expression of keratin 16 alters the adhesion, differentiation, and migration of mouse skin keratinocytes. Wawersik M, et al. Mol Biol Cell, 2000 Oct. PMID 11029038, Free PMC Article
    2. Aberrant heterodimerization of keratin 16 with keratin 6A in HaCaT keratinocytes results in diminished cellular migration. Trost A, et al. Mech Ageing Dev, 2010 May. PMID 20403371
    3. Identification of cytokeratin subspecies altered in rat experimental esophageal tumors by subtractive cloning. Wang DY, et al. Cancer Lett, 1996 Nov 12. PMID 8950218
    4. Keratin 16 regulates innate immunity in response to epidermal barrier breach. Lessard JC, et al. Proc Natl Acad Sci U S A, 2013 Nov 26. PMID 24218583, Free PMC Article
    5. Keratin 16 expression defines a subset of epithelial cells during skin morphogenesis and the hair cycle. Bernot KM, et al. J Invest Dermatol, 2002 Nov. PMID 12445204

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in establishment of skin barrier ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hair cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within intermediate filament cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in morphogenesis of an epithelium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intermediate filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 16
    Names
    keratin 14
    keratin 14-like
    keratin 16, type I
    type I keratin KA16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008752.2 → NP_001008752.1  keratin, type I cytoskeletal 16

      See identical proteins and their annotated locations for NP_001008752.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      Q6IFU9
      Related
      ENSRNOP00000019477.3, ENSRNOT00000019477.5
      Conserved Domains (2) summary
      pfam00038
      Location:105 → 413
      Filament; Intermediate filament protein
      cl14876
      Location:237 → 318
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      85669276..85672211 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247309.5 → XP_006247371.1  keratin, type I cytoskeletal 16 isoform X1

      Conserved Domains (2) summary
      pfam00038
      Location:105 → 413
      Filament; Intermediate filament protein
      cl14876
      Location:237 → 318
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein Strain
    Heading Accession and Version

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