Prss23 serine protease 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss23provided by MGI
Official Full Name: serine protease 23provided by MGI
Primary source: MGI:MGI:1923703
See related: Ensembl:ENSMUSG00000039405 AllianceGenome:MGI:1923703
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Spuve; 2310046G15Rik; 4930479H08Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in proteolysis. Located in extracellular space. Is expressed in several structures, including alimentary system; dentate gyrus subgranular zone; early conceptus; genitourinary system; and skeleton. Orthologous to human PRSS23 (serine protease 23). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 53.0), ovary adult (RPKM 40.2) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 49.9 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (89156988..89176399, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (89507783..89527187, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis.
Title: Silencing HE4 alleviates the renal fibrosis in lupus nephritis mice by regulating the C3/MMPs/prss axis.
Suggest a pivotal role for miR-532-prss23 axis in regulating cardiac endothelial cell function after myocardial infarction.
Title: MicroRNA-532 protects the heart in acute myocardial infarction, and represses prss23, a positive regulator of endothelial-to-mesenchymal transition.
The study demonstrates the distinct expression of Prss23 and Prss35 in the periimplantation uterus and the dispensable role of Prss35 in fertility and embryo development.
Title: Distinct spatiotemporal expression of serine proteases Prss23 and Prss35 in periimplantation mouse uterus and dispensable function of Prss35 in fertility.
HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia
Title: Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary.
Prss23 mRNA levels decreased transiently after ovulation induction and again in the postovulatory period
Title: The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Prss23 (e-PCR), detects polymorphism
- UniSTS:472917

AI790574 (e-PCR)
- UniSTS:179606

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine protease 23

Names: protease, serine 23

NP_001347681.2

EC 3.4.21.-

NP_001347682.2

EC 3.4.21.-

NP_001347683.2

EC 3.4.21.-

NP_001347684.1

EC 3.4.21.-

NP_001347685.1

EC 3.4.21.-

NP_001371077.2

EC 3.4.21.-

NP_001371080.1

EC 3.4.21.-

NP_001402962.1

EC 3.4.21.-

NP_001402963.1

EC 3.4.21.-

NP_083890.2

EC 3.4.21.-

XP_036009434.1

EC 3.4.21.-

XP_036009435.1

EC 3.4.21.-

XP_036009438.1

EC 3.4.21.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360752.2 → NP_001347681.2 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6

Related

ENSMUSP00000147183.2, ENSMUST00000207932.2
NM_001360753.2 → NP_001347682.2 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6
NM_001360754.2 → NP_001347683.2 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6
NM_001360755.2 → NP_001347684.1 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

Consensus CDS

CCDS21442.1

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6

UniProtKB/TrEMBL

Q8BZS4

Conserved Domains (1) summary

cl21584
Location:146 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001360756.2 → NP_001347685.1 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

Consensus CDS

CCDS21442.1

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6

UniProtKB/TrEMBL

Q8BZS4

Conserved Domains (1) summary

cl21584
Location:146 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001384148.2 → NP_001371077.2 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6
NM_001384151.2 → NP_001371080.1 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6

UniProtKB/TrEMBL

Q8BZS4

Conserved Domains (1) summary

cl21584
Location:146 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001416033.1 → NP_001402962.1 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6
NM_001416034.1 → NP_001402963.1 serine protease 23 precursor

Status: VALIDATED

Source sequence(s)

AC116326

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6
NM_029614.5 → NP_083890.2 serine protease 23 precursor

See identical proteins and their annotated locations for NP_083890.2

Status: VALIDATED

Source sequence(s)

AC116326

Consensus CDS

CCDS21442.1

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6

UniProtKB/TrEMBL

Q8BZS4

Related

ENSMUSP00000045191.6, ENSMUST00000041761.7

Conserved Domains (1) summary

cl21584
Location:146 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

89156988..89176399 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153541.1 → XP_036009434.1 serine protease 23 isoform X1

UniProtKB/TrEMBL

Q8BZS4

Conserved Domains (1) summary

cl21584
Location:187 → 295

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_036153542.1 → XP_036009435.1 serine protease 23 isoform X2

UniProtKB/TrEMBL

Q8BZS4

Conserved Domains (1) summary

cl21584
Location:154 → 262

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_036153545.1 → XP_036009438.1 serine protease 23 isoform X4

UniProtKB/Swiss-Prot

Q544M8, Q8VEG1, Q9D6X6

UniProtKB/TrEMBL

Q8BZS4

Conserved Domains (1) summary

cl21584
Location:146 → 254

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...