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    Serbp1 serpine1 mRNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 66870, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serbp1provided by MGI
    Official Full Name
    serpine1 mRNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1914120
    See related
    Ensembl:ENSMUSG00000036371 AllianceGenome:MGI:1914120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pairbp1; 1200009K13Rik; 9330147J08Rik
    Summary
    Enables ribosome binding activity; translation elongation factor binding activity; and translation repressor activity. Involved in ribosome hibernation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in cerebral cortex; early conceptus; and ovary. Orthologous to human SERBP1 (SERPINE1 mRNA binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 69.9), liver E14 (RPKM 49.8) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serbp1 in Genome Data Viewer
    Location:
    6 C1; 6 30.8 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (67243963..67266286)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (67266979..67289302)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16173 Neighboring gene predicted gene, 38825 Neighboring gene STARR-seq mESC enhancer starr_16175 Neighboring gene Sod1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_16176 Neighboring gene STARR-seq mESC enhancer starr_16180 Neighboring gene STARR-positive B cell enhancer ABC_E2787 Neighboring gene STARR-seq mESC enhancer starr_16184 Neighboring gene interleukin 12 receptor, beta 2 Neighboring gene predicted gene, 57761 Neighboring gene aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance. Smith PR, et al. Nat Commun, 2021 Nov 23. PMID 34815424, Free PMC Article
    2. The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation. Kosti A, et al. Genome Biol, 2020 Aug 6. PMID 32762776, Free PMC Article
    3. miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas. Li L, et al. J Mol Endocrinol, 2021 Nov 26. PMID 34723832
    4. A novel mRNA binding protein complex promotes localized plasminogen activator inhibitor-1 accumulation at the myoendothelial junction. Heberlein KR, et al. Arterioscler Thromb Vasc Biol, 2012 May. PMID 22383705, Free PMC Article
    5. Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human. Zhang L, et al. Mol Cell Endocrinol, 2008 Jun 11. PMID 18440126

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas.
      Title: miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas.
    2. The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
      Title: The RNA-binding protein SERBP1 functions as a novel oncogenic factor in glioblastoma by bridging cancer metabolism and epigenetic regulation.
    3. Spin1 regulates maternal transcripts post-transcriptionally and is involved in meiotic resumption
      Title: A tudor domain protein SPINDLIN1 interacts with the mRNA-binding protein SERBP1 and is involved in mouse oocyte meiotic resumption.
    4. The aim of this study was to assess the expression, localization and hormonal regulation of two novel P(4) receptor candidates, P(4) receptor membrane component (PGRMC) 1 and PGRMC2, as well as the PGRMC1 partner Serpine 1 mRNA binding protein (SERBP1).
      Title: Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosome binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables translation elongation factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation repressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation repressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in PML body organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in PML body organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome hibernation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ribosome hibernation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membraneless organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SERPINE1 mRNA-binding protein 1
    Names
    PAI-1 mRNA-binding protein
    PAI-RBP1
    PAI1 RNA-binding protein 1
    plasminogen activator inhibitor 1 RNA-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113564.1 → NP_001107036.1  SERPINE1 mRNA-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001107036.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC130822, AK144764, BY083551
      Consensus CDS
      CCDS85061.1
      UniProtKB/TrEMBL
      Q3UMP4, Q3V274
      Related
      ENSMUSP00000144713.2, ENSMUST00000203436.3
      Conserved Domains (2) summary
      pfam04774
      Location:189 → 306
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5 → 119
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    2. NM_001113565.1 → NP_001107037.1  SERPINE1 mRNA-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001107037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC130822, AK004678, AK010860
      Consensus CDS
      CCDS85060.1
      UniProtKB/TrEMBL
      Q3UJK2
      Related
      ENSMUSP00000144913.2, ENSMUST00000203077.3
      Conserved Domains (2) summary
      pfam04774
      Location:189 → 297
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5 → 119
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    3. NM_001113566.1 → NP_001107038.1  SERPINE1 mRNA-binding protein 1 isoform 4

      See identical proteins and their annotated locations for NP_001107038.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has two alternate splice sites in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
      Source sequence(s)
      AC130822, BC030502, BY083551
      Consensus CDS
      CCDS85062.1
      UniProtKB/TrEMBL
      Q3UEI6, Q3V274
      Related
      ENSMUSP00000145472.2, ENSMUST00000204293.3
      Conserved Domains (2) summary
      pfam04774
      Location:189 → 291
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5 → 152
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    4. NM_025814.2 → NP_080090.2  SERPINE1 mRNA-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_080090.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC130822, AK004678
      Consensus CDS
      CCDS20219.1
      UniProtKB/Swiss-Prot
      Q8BHS2, Q8BHU0, Q91WP3, Q9CSN0, Q9CY58, Q9DBY6
      UniProtKB/TrEMBL
      Q3UJK2
      Related
      ENSMUSP00000039110.5, ENSMUST00000042990.7
      Conserved Domains (2) summary
      pfam04774
      Location:189 → 312
      HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
      pfam16174
      Location:5 → 119
      IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      67243963..67266286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CY58.2 GenPept UniProtKB/Swiss-Prot:Q9CY58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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