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    Sulf1 sulfatase 1 [ Mus musculus (house mouse) ]

    Gene ID: 240725, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sulf1provided by MGI
    Official Full Name
    sulfatase 1provided by MGI
    Primary source
    MGI:MGI:2138563
    See related
    Ensembl:ENSMUSG00000016918 AllianceGenome:MGI:2138563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MSulf-1; mKIAA1077
    Summary
    Enables N-acetylglucosamine-6-sulfatase activity. Involved in several processes, including esophagus smooth muscle contraction; glomerular filtration; and skeletal system development. Located in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; limb; lower urogenital tract; and sensory organ. Orthologous to human SULF1 (sulfatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 24.1), CNS E11.5 (RPKM 12.3) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sulf1 in Genome Data Viewer
    Location:
    1 A3; 1 3.35 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (12762421..12946090)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (12692197..12861192)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 17644 Neighboring gene STARR-seq mESC enhancer starr_00233 Neighboring gene STARR-seq mESC enhancer starr_00244 Neighboring gene solute carrier organic anion transporter family, member 5A1 Neighboring gene STARR-positive B cell enhancer ABC_E1989 Neighboring gene STARR-seq mESC enhancer starr_00248 Neighboring gene STARR-seq mESC enhancer starr_00251 Neighboring gene STARR-seq mESC enhancer starr_00254 Neighboring gene STARR-seq mESC enhancer starr_00260 Neighboring gene STARR-seq mESC enhancer starr_00263 Neighboring gene developmental pluripotency associated 5A pseudogene Neighboring gene predicted gene, 39592

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylglucosamine-6-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables N-acetylglucosamine-6-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables N-acetylglucosamine-6-sulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables arylsulfatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables arylsulfatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables glycosaminoglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cartilage condensation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cartilage development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell adhesion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in chondrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in esophagus smooth muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glial cell-derived neurotrophic factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glomerular basement membrane development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glomerular basement membrane development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in heparan sulfate proteoglycan metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in heparan sulfate proteoglycan metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innervation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in limb joint morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of prostatic bud formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of vascular endothelial growth factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sulfur compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi stack IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane raft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    extracellular sulfatase Sulf-1
    Names
    N-acetylglucosamine-6-sulfatase
    arylsulfatase
    NP_001185494.1
    NP_001185495.1
    NP_758498.1
    XP_006495573.1
    XP_006495575.1
    XP_006495576.1
    XP_036020584.1
    XP_036020589.1
    XP_036020591.1
    XP_036020594.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198565.2NP_001185494.1  extracellular sulfatase Sulf-1 precursor

      See identical proteins and their annotated locations for NP_001185494.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) may represent the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC126044, AC134787, AC136316
      Consensus CDS
      CCDS14820.1
      UniProtKB/Swiss-Prot
      Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007
      UniProtKB/TrEMBL
      A0A0R4J2D2
      Related
      ENSMUSP00000137523.2, ENSMUST00000177608.8
      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    2. NM_001198566.2NP_001185495.1  extracellular sulfatase Sulf-1 precursor

      See identical proteins and their annotated locations for NP_001185495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC126044, AC134787, AC136316
      Consensus CDS
      CCDS14820.1
      UniProtKB/Swiss-Prot
      Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007
      UniProtKB/TrEMBL
      A0A0R4J2D2
      Related
      ENSMUSP00000136014.2, ENSMUST00000180062.8
      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    3. NM_172294.2NP_758498.1  extracellular sulfatase Sulf-1 precursor

      See identical proteins and their annotated locations for NP_758498.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC126044, AC134787, AC136316
      Consensus CDS
      CCDS14820.1
      UniProtKB/Swiss-Prot
      Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007
      UniProtKB/TrEMBL
      A0A0R4J2D2
      Related
      ENSMUSP00000085949.4, ENSMUST00000088585.10
      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      12762421..12946090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164698.1XP_036020591.1  extracellular sulfatase Sulf-1 isoform X3

      UniProtKB/TrEMBL
      A0A0R4J2D2
      Related
      ENSMUSP00000141153.2, ENSMUST00000186051.7
      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    2. XM_006495510.4XP_006495573.1  extracellular sulfatase Sulf-1 isoform X1

      See identical proteins and their annotated locations for XP_006495573.1

      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    3. XM_036164696.1XP_036020589.1  extracellular sulfatase Sulf-1 isoform X2

      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767808
      ALP_like; alkaline phosphatases and sulfatases
    4. XM_006495513.5XP_006495576.1  extracellular sulfatase Sulf-1 isoform X1

      See identical proteins and their annotated locations for XP_006495576.1

      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    5. XM_006495512.4XP_006495575.1  extracellular sulfatase Sulf-1 isoform X1

      See identical proteins and their annotated locations for XP_006495575.1

      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    6. XM_036164691.1XP_036020584.1  extracellular sulfatase Sulf-1 isoform X1

      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases
    7. XM_036164701.1XP_036020594.1  extracellular sulfatase Sulf-1 isoform X4

      UniProtKB/Swiss-Prot
      Q6ZPZ0, Q8BLJ0, Q8C1D3, Q8K007
      UniProtKB/TrEMBL
      A0A0R4J2D2
      Conserved Domains (3) summary
      cd16147
      Location:42384
      G6S; glucosamine (N-acetyl)-6-sulfatase(G6S, GNS) AND sulfatase 1(SULF1)
      pfam12548
      Location:534674
      DUF3740; Sulfatase protein
      cl23718
      Location:767816
      ALP_like; alkaline phosphatases and sulfatases