Anp32a acidic nuclear phosphoprotein 32 family member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Anp32aprovided by MGI
Official Full Name: acidic nuclear phosphoprotein 32 family member Aprovided by MGI
Primary source: MGI:MGI:108447
See related: Ensembl:ENSMUSG00000032249 AllianceGenome:MGI:108447
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LANP; pp32; Anp32; PHAP1; I1PP2A
Summary: Predicted to enable histone binding activity. Predicted to be involved in nucleocytoplasmic transport and regulation of apoptotic process. Located in nuclear matrix. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to several human genes including ANP32A (acidic nuclear phosphoprotein 32 family member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 178.7), CNS E14 (RPKM 62.2) and 15 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 9 B; 9 33.68 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (62248637..62286084)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (62341343..62378804)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.
Title: PB2 residue 473 contributes to the mammalian virulence of H7N9 avian influenza virus by modulating viral polymerase activity via ANP32A.
Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
Title: Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza Virus.
Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
Title: Hypoxia and Wnt signaling inversely regulate expression of chondroprotective molecule ANP32A in articular cartilage.
ANP32A/ATM axis discovered in cartilage is also present in brain and bone.
Title: ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.
The findings of this study reveal that upregulated ANP32A induced-suppressing histone acetylation may underlie the cognitive decline in neurodegenerative disease.
Title: Inhibition of Histone Acetylation by ANP32A Induces Memory Deficits.
our study reveals that ANP32A dysregulation may be a critical factor contributing to acute megakaryoblastic leukemia
Title: ANP32A dysregulation contributes to abnormal megakaryopoiesis in acute megakaryoblastic leukemia.
We conclude that downregulating ANP32A rescues synaptic plasticity and memory ability by reducing INHAT formation and unmasking histone for hyperacetylation
Title: Downregulating ANP32A rescues synapse and memory loss via chromatin remodeling in Alzheimer model.
The variation of expression levels and distribution of ANP32A in the developing brain would imply that ANP32A may play an important role in mammalian brain development
Title: The expression and distributions of ANP32A in the developing brain.
depleting the Leucine-rich Acidic Nuclear Protein (LANP)-an ATXN1 binding inhibitor of histone acetylation-reverses aspects of Spinocerebellar ataxia type 1 neuritic pathology.
Title: LANP mediates neuritic pathology in Spinocerebellar ataxia type 1.
LANP directly regulates expression of the neurofilament light chain, an important neuron-specific cytoskeletal gene, by binding to the promoter of this gene and modulating histone acetylation levels
Title: Neuronal differentiation is regulated by leucine-rich acidic nuclear protein (LANP), a member of the inhibitor of histone acetyltransferase complex.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

RH125302 (e-PCR)
- UniSTS:162124

NoName (e-PCR)
- UniSTS:483159

Anp32a (e-PCR), detects polymorphism
- UniSTS:506727

NoName (e-PCR)
- UniSTS:236155

ANP32C__4314 (e-PCR)
- UniSTS:463541

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in nucleocytoplasmic transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear matrix	IPI Inferred from Physical Interaction more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: acidic leucine-rich nuclear phosphoprotein 32 family member A

Names: acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; acidic nuclear phosphoprotein 32; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; vacidic (leucine-rich) nuclear phosphoprotein 32 family, member A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411151.1 → NP_001398080.1 acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 2

Status: VALIDATED

Source sequence(s)

AC113291, AC121813
NM_001411152.1 → NP_001398081.1 acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 3

Status: VALIDATED

Source sequence(s)

AC113291, AC121813

UniProtKB/TrEMBL

D3Z7M9

Related

ENSMUSP00000122165.2, ENSMUST00000135395.8
NM_009672.4 → NP_033802.2 acidic leucine-rich nuclear phosphoprotein 32 family member A isoform 1

See identical proteins and their annotated locations for NP_033802.2

Status: VALIDATED

Source sequence(s)

AC113291, AC121813

Consensus CDS

CCDS40663.1

UniProtKB/Swiss-Prot

O35381, P97437

Related

ENSMUSP00000082652.7, ENSMUST00000085519.13

Conserved Domains (3) summary

sd00035
Location:90 → 113

LRR_NTF; leucine-rich repeat [structural motif]

pfam14580
Location:71 → 146

LRR_9; Leucine-rich repeat

NF033189
Location:9 → 128

internalin_A; class 1 internalin InlA