Lgi3 leucine-rich repeat LGI family, member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lgi3provided by MGI
Official Full Name: leucine-rich repeat LGI family, member 3provided by MGI
Primary source: MGI:MGI:2182619
See related: Ensembl:ENSMUSG00000033595 AllianceGenome:MGI:2182619
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Involved in regulation of exocytosis. Located in juxtaparanode region of axon and synaptic vesicle. Is expressed in several structures, including autopod; gut; nervous system; respiratory system; and retina. Orthologous to human LGI3 (leucine rich repeat LGI family member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 127.1), cerebellum adult (RPKM 61.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D2; 14 36.32 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (70765982..70775764)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (70528547..70538324)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
Title: Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity.
Taken together, these results support the critical involvement of LGI3 in the cytokine network by interplaying with multiple adipokines, cytokines and signaling proteins.
Title: Leucine-rich glioma inactivated 3: Integrative analyses support its role in the cytokine network.
findings show LGI3 and TNF-alpha upregulated each other in 3T3-L1 cells; study suggests LGI3 is a pro-inflammatory adipokine and forms a positive feedback loop with TNF-alpha; propose that LGI3 is a member of adipokine network that plays regulatory roles in obesity-associated adipose tissue inflammation
Title: Leucine-rich glioma inactivated 3 and tumor necrosis factor-α regulate mutually through NF-κB.
results suggested that LGI3 may participate in adipose tissue homeostasis by negatively regulating adiponectin
Title: Leucine-rich glioma inactivated 3 associates negatively with adiponectin.
Data suggest that leucine-rich glioma inactivated 3 (LGI3) may be a candidate adipokine that is perturbed in obesity and suppresses adipogenesis through its receptor, ADAM23.
Title: Leucine-rich glioma inactivated 3 regulates adipogenesis through ADAM23.
LGI3 interacts with Flo1 in the brain, and LGI3/Flo1 mediates APP trafficking and exosome formation in neuronal cells: reveals the details of the intracellular transport system and even the secretion pathway in the brain.
Title: LGI3 interacts with flotillin-1 to mediate APP trafficking and exosome formation.
we propose that LGI3 is a neuritogenic factor whose signaling pathway involves Akt-mediated FAK activation.
Title: Leucine-rich glioma inactivated 3 induces neurite outgrowth through Akt and focal adhesion kinase.
LGI3 gene widespread expression in the brain suggests that its transcripts might be involved in a common cellular process present in different neuronal types.
Title: Regional distribution of the leucine-rich glioma inactivated (LGI) gene family transcripts in the adult mouse brain.
LGI3 may play a regulatory role in neuronal exocytosis via its interaction with syntaxin 1.
Title: Leucine-rich glioma inactivated 3 associates with syntaxin 1.
Data show that LGI3 localizes to the endocytic pathway and its accumulation is caused by endocytic perturbation.
Title: Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI841179 (e-PCR)
- UniSTS:165914

AW049851 (e-PCR)
- UniSTS:180692

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: leucine-rich repeat LGI family member 3

Names: leubrin; leucine-rich glioma-inactivated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001425646.1 → NP_001412575.1 leucine-rich repeat LGI family member 3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC122268

UniProtKB/Swiss-Prot

Q8K406
NM_145219.5 → NP_660254.1 leucine-rich repeat LGI family member 3 isoform 1 precursor

See identical proteins and their annotated locations for NP_660254.1

Status: VALIDATED

Source sequence(s)

AC122268

Consensus CDS

CCDS27255.1

UniProtKB/Swiss-Prot

Q8K406

UniProtKB/TrEMBL

Q3V1R3

Related

ENSMUSP00000046705.7, ENSMUST00000047331.8

Conserved Domains (4) summary

TIGR00864
Location:143 → 218

PCC; polycystin cation channel protein

sd00031
Location:68 → 89

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:113 → 172

LRR_8; Leucine rich repeat

pfam03736
Location:270 → 308

EPTP; EPTP domain