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    Prss2 serine protease 2 [ Mus musculus (house mouse) ]

    Gene ID: 22072, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss2provided by MGI
    Official Full Name
    serine protease 2provided by MGI
    Primary source
    MGI:MGI:102759
    See related
    Ensembl:ENSMUSG00000057163 AllianceGenome:MGI:102759
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ta; TRY8; TRYP; Try2; Tesp4
    Summary
    Enables serine-type endopeptidase activity. Predicted to be involved in several processes, including collagen catabolic process; response to caffeine; and response to nicotine. Located in collagen-containing extracellular matrix. Is expressed in alimentary system; genitourinary system; and spleen. Orthologous to human PRSS2 (serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See Prss2 in Genome Data Viewer
    Location:
    6 B1; 6 19.67 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41498710..41502013)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41521776..41525079)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene T cell receptor beta chain Neighboring gene STARR-seq mESC enhancer starr_15699 Neighboring gene serine protease 3 like Neighboring gene STARR-seq mESC enhancer starr_15700 Neighboring gene serine protease 1 (trypsin 1) Neighboring gene STARR-positive B cell enhancer mm9_chr6:41480095-41480396 Neighboring gene proline-rich polypeptide 3 pseudogene Neighboring gene T cell receptor beta joining 1-1 Neighboring gene T cell receptor beta, D region 1

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in collagen catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in digestion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to acetaldehyde IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to caffeine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    anionic trypsin-2
    Names
    anionic trypsin II
    pretrypsinogen II
    protease, serine 2
    trypsin 2
    trypsinogen 20
    NP_033456.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_006980.1 

      Range
      630982..634285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_009430.2NP_033456.1  anionic trypsin-2 precursor

      See identical proteins and their annotated locations for NP_033456.1

      Status: VALIDATED

      Source sequence(s)
      AK003082, BB841364
      Consensus CDS
      CCDS20050.1
      UniProtKB/Swiss-Prot
      P07146
      UniProtKB/TrEMBL
      Q3V2E0, Q792Y6
      Related
      ENSMUSP00000065393.5, ENSMUST00000070380.5
      Conserved Domains (2) summary
      smart00020
      Location:23239
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:24242
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      41498710..41502013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)