Mocs3 molybdenum cofactor synthesis 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mocs3provided by MGI
Official Full Name: molybdenum cofactor synthesis 3provided by MGI
Primary source: MGI:MGI:1916622
See related: Ensembl:ENSMUSG00000074576 AllianceGenome:MGI:1916622
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Uba4; 1700020H17Rik
Summary: Predicted to enable URM1 activating enzyme activity; nucleotidyltransferase activity; and sulfurtransferase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process; protein urmylation; and tRNA wobble position uridine thiolation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in central nervous system; retina inner nuclear layer; retina layer; and retina outer nuclear layer. Orthologous to human MOCS3 (molybdenum cofactor synthesis 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 2 H3; 2 88.5 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (168072542..168074223)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (168230622..168232303)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:234612

NoName (e-PCR)
- UniSTS:493293

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables URM1 activating enzyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables URM1 activating enzyme activity	ISO Inferred from Sequence Orthology more info
enables URM1 activating enzyme activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin-synthase sulfurtransferase activity	ISO Inferred from Sequence Orthology more info
enables molybdopterin-synthase sulfurtransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleotidyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables sulfurtransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables sulfurtransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiosulfate sulfurtransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in Mo-molybdopterin cofactor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in molybdopterin cofactor biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in molybdopterin cofactor metabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein urmylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA thio-modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA thio-modification	ISS Inferred from Sequence or Structural Similarity more info
involved_in tRNA wobble position uridine thiolation	IBA Inferred from Biological aspect of Ancestor more info
involved_in tRNA wobble position uridine thiolation	IEA Inferred from Electronic Annotation more info
involved_in tRNA wobble uridine modification	ISO Inferred from Sequence Orthology more info
involved_in tRNA wobble uridine modification	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: adenylyltransferase and sulfurtransferase MOCS3

Names: MPT synthase sulfurylase

NP_001153802.1

EC 2.7.7.80

EC 2.8.1.11

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160330.1 → NP_001153802.1 adenylyltransferase and sulfurtransferase MOCS3

See identical proteins and their annotated locations for NP_001153802.1

Status: VALIDATED

Source sequence(s)

BE133066, BE333092, BG083535, BX005039, BY727851

Consensus CDS

CCDS50802.1

UniProtKB/Swiss-Prot

A2BDX3

Related

ENSMUSP00000096670.4, ENSMUST00000099071.5

Conserved Domains (3) summary

PRK07411
Location:56 → 460

PRK07411; hypothetical protein; Validated

cd00757
Location:62 → 285

ThiF_MoeB_HesA_family; ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD ...

cd01526
Location:327 → 460

RHOD_ThiF; Member of the Rhodanese Homology Domain superfamily. This CD includes several putative molybdopterin synthase sulfurylases including the molybdenum cofactor biosynthetic protein (CnxF) of Aspergillus nidulans and the molybdenum cofactor synthesis protein ...