Ccny cyclin Y [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnyprovided by MGI
Official Full Name: cyclin Yprovided by MGI
Primary source: MGI:MGI:1915224
See related: Ensembl:ENSMUSG00000024286 AllianceGenome:MGI:1915224
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700025H17Rik; 3110050L10Rik; 4631402G10Rik; 5730405I09Rik
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in several processes, including G2/M transition of mitotic cell cycle; positive regulation of cyclin-dependent protein serine/threonine kinase activity; and regulation of canonical Wnt signaling pathway. Part of cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including cerebral cortex; genitourinary system; gut; mammary gland; and spleen. Orthologous to human CCNY (cyclin Y). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 25.9), ovary adult (RPKM 20.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 4.91 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (9312304..9450188, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (9312304..9450154, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway.
Title: Cyclin Y regulates spatial learning and memory flexibility through distinct control of the actin pathway.
Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Title: Ccny knockout mice display an enhanced susceptibility to kainic acid-induced epilepsy.
Here we show that Cyclin Y-like 1 (Ccnyl1) and Cyclin Y (Ccny) have overlapping function and are crucial for mouse embryonic development and mammary stem/progenitor cell functions. Double knockout of Ccnys results in embryonic lethality at E16.5
Title: Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells.
these results provide a new link between CCNY and lipid metabolism in mice.
Title: Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.
CDK16 isolated from testis was unphosphorylated, interacted with CCNY, and exhibited kinase activity.
Title: Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic cyclin-dependent protein kinase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cyclin-Y

Names: cyclin fold protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026484.4 → NP_080760.2 cyclin-Y

See identical proteins and their annotated locations for NP_080760.2

Status: VALIDATED

Source sequence(s)

AC108777, AK014201, AK014507, AK028696, AW048376

Consensus CDS

CCDS29050.1

UniProtKB/Swiss-Prot

Q8BGU5, Q8CI87, Q9CYN5

Related

ENSMUSP00000050001.5, ENSMUST00000053917.6

Conserved Domains (1) summary

cd20540
Location:166 → 262

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

9312304..9450188 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250583.2 → XP_030106443.1 cyclin-Y isoform X2

Conserved Domains (1) summary

pfam00134
Location:101 → 223

Cyclin_N; Cyclin, N-terminal domain
XM_030250584.2 → XP_030106444.1 cyclin-Y isoform X4

Conserved Domains (1) summary

cd20540
Location:27 → 123

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
XM_036161266.1 → XP_036017159.1 cyclin-Y isoform X4

Conserved Domains (1) summary

cd20540
Location:27 → 123

CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family
XM_030250582.1 → XP_030106442.1 cyclin-Y isoform X1

Conserved Domains (1) summary

pfam00134
Location:89 → 211

Cyclin_N; Cyclin, N-terminal domain
XM_036161265.1 → XP_036017158.1 cyclin-Y isoform X3

Conserved Domains (1) summary

cl40454
Location:166 → 193

CYCLIN_SF; Cyclin box fold superfamily