Slc26a7 solute carrier family 26, member 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc26a7provided by MGI
Official Full Name: solute carrier family 26, member 7provided by MGI
Primary source: MGI:MGI:2384791
See related: Ensembl:ENSMUSG00000040569 AllianceGenome:MGI:2384791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables chloride channel activity and chloride:bicarbonate antiporter activity. Involved in several processes, including bicarbonate transport; carboxylic acid transport; and inorganic anion transmembrane transport. Acts upstream of or within chloride transport. Located in basolateral plasma membrane. Is expressed in several structures, including alimentary system; brain; limb; respiratory system; and sensory organ. Used to study congenital hypothyroidism. Orthologous to human SLC26A7 (solute carrier family 26 member 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in limb E14.5 (RPKM 6.8), subcutaneous fat pad adult (RPKM 4.1) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A1; 4 6.24 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (14502430..14621946, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (14502430..14621946, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice.
Title: The iodide transporter Slc26a7 impacts thyroid function more strongly than Slc26a4 in mice.
SLC26A7 constitutes the thiocyanate-selective anion conductance of the basolateral membrane of the retinal pigment epithelium.
Title: SLC26A7 constitutes the thiocyanate-selective anion conductance of the basolateral membrane of the retinal pigment epithelium.
Study reports homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous congenital hypothyroidism and shows that goitrous hypothyroidism also occurs in Slc26a7-null mice.
Title: Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.
Slc26a1, Slc26a6 and Slc26a7 are novel participants in the extracellular transport of bicarbonate during enamel maturation.
Title: SLC26A Gene Family Participate in pH Regulation during Enamel Maturation.
Slc26a7 chloride channel activity and localization in mouse Reissner's membrane epithelium
Title: Slc26a7 chloride channel activity and localization in mouse Reissner's membrane epithelium.
SLC26A7 dysfunction should be investigated as a potential cause of unexplained distal renal tubular acidosis
Title: Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion.
Suggest that the increase in Slc26a7 expression caused by deletion of AE1 represents an adaptive response, indicating that Slc26a7 contributes to the regulation of acid-base balance by the kidney.
Title: Increased acid load and deletion of AE1 increase Slc26a7 expression.
CAII deficiency results in a significant decrease in the gene and protein expression of bicarbonate transport proteins from Slc26 gene family - Slc26a4 (pendrin) and Slc26a7.
Title: Decreased expression of Slc26a4 (Pendrin) and Slc26a7 in the kidneys of carbonic anhydrase II-deficient mice.
Slc26a7 is expressed in the proximal tubule and thick ascending limb of the loop of Henle, and it may therefore contribute to anion transport in these nephron segments
Title: Immunolocalization of anion transporter Slc26a7 in mouse kidney.
findings reveal that SLC26A7 functions as a unique Cl(-) channel that is regulated by intracellular H(+)
Title: SLC26A7 is a Cl- channel regulated by intracellular pH.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc26a7 (e-PCR), detects polymorphism
- UniSTS:547064

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride channel activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride channel activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride:bicarbonate antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables chloride:bicarbonate antiporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic anion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxalate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables oxalate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in bicarbonate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in chloride transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chloride transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in gastric acid secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in gluconate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iodide transport	IDA Inferred from Direct Assay more info	PubMed
involved_in iodide transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iodide transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic anion transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitrate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxalate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxalate transport	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: anion exchange transporter

Names: anion exchanger Slc26a7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145947.2 → NP_666059.2 anion exchange transporter

See identical proteins and their annotated locations for NP_666059.2

Status: VALIDATED

Source sequence(s)

AF345194, AK054327

Consensus CDS

CCDS17979.1

UniProtKB/Swiss-Prot

A2AJZ4, B1AWS0, Q8R2Z3

Related

ENSMUSP00000041789.8, ENSMUST00000042221.14

Conserved Domains (2) summary

cd07042
Location:495 → 632

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

TIGR00815
Location:33 → 637

sulP; high affinity sulphate transporter 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

14502430..14621946 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537723.4 → XP_006537786.1 anion exchange transporter isoform X1

See identical proteins and their annotated locations for XP_006537786.1

Conserved Domains (2) summary

cd07042
Location:533 → 668

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:47 → 444

Sulfate_transp; Sulfate permease family
XM_006537722.4 → XP_006537785.1 anion exchange transporter isoform X1

See identical proteins and their annotated locations for XP_006537785.1

Conserved Domains (2) summary

cd07042
Location:533 → 668

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:47 → 444

Sulfate_transp; Sulfate permease family