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    Adat1 adenosine deaminase, tRNA-specific 1 [ Mus musculus (house mouse) ]

    Gene ID: 30947, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Adat1provided by MGI
    Official Full Name
    adenosine deaminase, tRNA-specific 1provided by MGI
    Primary source
    MGI:MGI:1353631
    See related
    Ensembl:ENSMUSG00000031949 AllianceGenome:MGI:1353631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MMADAT1
    Summary
    Predicted to enable RNA binding activity and tRNA-specific adenosine deaminase activity. Predicted to be involved in tRNA processing. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.2), limb E14.5 (RPKM 2.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adat1 in Genome Data Viewer
    Location:
    8 E1; 8 58.23 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112685552..112718938, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111958920..111992307, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 231 Neighboring gene predicted gene, 36531 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114464460-114464569 Neighboring gene STARR-seq mESC enhancer starr_22729 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114500469-114500652 Neighboring gene STARR-positive B cell enhancer ABC_E6687 Neighboring gene STARR-positive B cell enhancer ABC_E1376 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene telomeric repeat binding factor 2, interacting protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence, genomic organization and functional expression of the murine tRNA-specific adenosine deaminase ADAT1. Maas S, et al. Gene, 2000 Feb 8. PMID 10675613
    2. Genomic clustering of tRNA-specific adenosine deaminase ADAT1 and two tRNA synthetases. Maas S, et al. Mamm Genome, 2001 May. PMID 11331948
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA-specific adenosine deaminase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables tRNA-specific adenosine-37 deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-specific adenosine deaminase 1
    Names
    tRNA-specific adenosine-37 deaminase
    NP_001344113.1
    NP_001344114.1
    NP_001344115.1
    NP_038953.1
    XP_006531138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357184.1 → NP_001344113.1  tRNA-specific adenosine deaminase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK035614, AK082399, AK161044
      UniProtKB/TrEMBL
      D3Z6J6
      Related
      ENSMUSP00000113201.2, ENSMUST00000120457.2
      Conserved Domains (1) summary
      pfam02137
      Location:63 → 371
      A_deamin; Adenosine-deaminase (editase) domain

    2. NM_001357185.1 → NP_001344114.1  tRNA-specific adenosine deaminase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC114648, AK082399, AK161044
      Consensus CDS
      CCDS90464.1
      Related
      ENSMUSP00000117279.2, ENSMUST00000139820.8
      Conserved Domains (1) summary
      pfam02137
      Location:63 → 453
      A_deamin; Adenosine-deaminase (editase) domain

    3. NM_001357186.1 → NP_001344115.1  tRNA-specific adenosine deaminase 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC114648, AC115914
      UniProtKB/TrEMBL
      D3Z6J6
      Conserved Domains (1) summary
      pfam02137
      Location:63 → 402
      A_deamin; Adenosine-deaminase (editase) domain

    4. NM_013925.5 → NP_038953.1  tRNA-specific adenosine deaminase 1 isoform 1

      See identical proteins and their annotated locations for NP_038953.1

      Status: VALIDATED

      Source sequence(s)
      AC115914, AK082399
      Consensus CDS
      CCDS22684.1
      UniProtKB/Swiss-Prot
      Q3TU04, Q8CBP0, Q8VE23, Q9JHI2
      Related
      ENSMUSP00000034427.6, ENSMUST00000034427.12
      Conserved Domains (1) summary
      pfam02137
      Location:63 → 492
      A_deamin; Adenosine-deaminase (editase) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      112685552..112718938 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531075.5 → XP_006531138.1  tRNA-specific adenosine deaminase 1 isoform X1

      UniProtKB/TrEMBL
      D3Z6J6
      Conserved Domains (1) summary
      pfam02137
      Location:63 → 410
      A_deamin; Adenosine-deaminase (editase) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHI2.1 GenPept UniProtKB/Swiss-Prot:Q9JHI2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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