U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sncaip synuclein, alpha interacting protein (synphilin) [ Mus musculus (house mouse) ]

    Gene ID: 67847, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sncaipprovided by MGI
    Official Full Name
    synuclein, alpha interacting protein (synphilin)provided by MGI
    Primary source
    MGI:MGI:1915097
    See related
    Ensembl:ENSMUSG00000024534 AllianceGenome:MGI:1915097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SYPH1; 2810407O15Rik; 4933427B05Rik
    Summary
    Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in dopamine metabolic process; regulation of inclusion body assembly; and regulation of neurotransmitter secretion. Predicted to be located in cytoplasmic ribonucleoprotein granule and nucleoplasm. Is expressed in several structures, including alimentary system; branchial arch; cerebral cortex; genitourinary system; and ureter. Orthologous to human SNCAIP (synuclein alpha interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E14 (RPKM 5.1), whole brain E14.5 (RPKM 5.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sncaip in Genome Data Viewer
    Location:
    18 D1; 18 28.27 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (52900872..53049007)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (52767811..52915935)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41725 Neighboring gene glycerol kinase-like 1 Neighboring gene STARR-seq mESC enhancer starr_44606 Neighboring gene STARR-seq mESC enhancer starr_44607 Neighboring gene predicted gene, 50457 Neighboring gene STARR-seq mESC enhancer starr_44608 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_44612 Neighboring gene STARR-positive B cell enhancer ABC_E5658 Neighboring gene STARR-positive B cell enhancer ABC_E7586 Neighboring gene STARR-positive B cell enhancer ABC_E4250 Neighboring gene sorting nexin 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107459

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within dopamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of inclusion body assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    synphilin-1
    Names
    alpha-synuclein-interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199151.2NP_001186080.1  synphilin-1 isoform 1

      See identical proteins and their annotated locations for NP_001186080.1

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      Consensus CDS
      CCDS57124.1
      UniProtKB/TrEMBL
      G5E848, Q3TVI3, Q4KMM4
      Related
      ENSMUSP00000137367.2, ENSMUST00000178678.8
      Conserved Domains (4) summary
      PHA02874
      Location:421509
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:348381
      ANK; ANK repeat [structural motif]
      pfam16700
      Location:511554
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      pfam12796
      Location:353486
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001199153.2NP_001186082.1  synphilin-1 isoform 1

      See identical proteins and their annotated locations for NP_001186082.1

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      Consensus CDS
      CCDS57124.1
      UniProtKB/TrEMBL
      G5E848, Q3TVI3, Q4KMM4
      Related
      ENSMUSP00000025413.7, ENSMUST00000025413.14
      Conserved Domains (4) summary
      PHA02874
      Location:421509
      PHA02874; ankyrin repeat protein; Provisional
      sd00045
      Location:348381
      ANK; ANK repeat [structural motif]
      pfam16700
      Location:511554
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      pfam12796
      Location:353486
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001199154.2NP_001186083.1  synphilin-1 isoform 2

      See identical proteins and their annotated locations for NP_001186083.1

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      Consensus CDS
      CCDS37820.2
      UniProtKB/TrEMBL
      E9Q4E2, Q3V1N2
      Related
      ENSMUSP00000137549.2, ENSMUST00000178011.8
      Conserved Domains (5) summary
      cd00204
      Location:344509
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:390486
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:349404
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:511554
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:348381
      ANK; ANK repeat [structural motif]
    4. NM_001403646.1NP_001390575.1  synphilin-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      UniProtKB/TrEMBL
      J3QNK1
      Related
      ENSMUSP00000136838.2, ENSMUST00000179625.8
    5. NM_001403647.1NP_001390576.1  synphilin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      UniProtKB/TrEMBL
      G5E848, Q3TVI3, Q4KMM4
    6. NM_001403648.1NP_001390577.1  synphilin-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      UniProtKB/TrEMBL
      G5E848, Q3TVI3, Q4KMM4
    7. NM_026408.5NP_080684.3  synphilin-1 isoform 2

      See identical proteins and their annotated locations for NP_080684.3

      Status: VALIDATED

      Source sequence(s)
      AC121943, AC124178
      Consensus CDS
      CCDS37820.2
      UniProtKB/TrEMBL
      E9Q4E2, Q3V1N2
      Related
      ENSMUSP00000127189.3, ENSMUST00000163742.9
      Conserved Domains (5) summary
      cd00204
      Location:344509
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:390486
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:349404
      Ank_4; Ankyrin repeats (many copies)
      pfam16700
      Location:511554
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      sd00045
      Location:348381
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      52900872..53049007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317971.2XP_017173460.1  synphilin-1 isoform X2

      UniProtKB/TrEMBL
      J3QNK1
      Conserved Domains (3) summary
      sd00045
      Location:361393
      ANK; ANK repeat [structural motif]
      pfam16700
      Location:451494
      SNCAIP_SNCA_bd; Synphilin-1 alpha-Synuclein-binding domain
      pfam12796
      Location:334426
      Ank_2; Ankyrin repeats (3 copies)