Cdk5rap3 CDK5 regulatory subunit associated protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdk5rap3provided by MGI
Official Full Name: CDK5 regulatory subunit associated protein 3provided by MGI
Primary source: MGI:MGI:1933126
See related: Ensembl:ENSMUSG00000018669 AllianceGenome:MGI:1933126
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C53; IC53; LZAP; HSF-27; MST016; 1810007E24Rik
Summary: Enables ubiquitin-like protein ligase binding activity. Involved in several processes, including definitive erythrocyte differentiation; liver development; and protein ufmylation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including brain; hemolymphoid system gland; liver; retina; and seminiferous cord. Orthologous to human CDK5RAP3 (CDK5 regulatory subunit associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 22.6), genital fat pad adult (RPKM 15.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 60.16 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (96798251..96807359, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (96907425..96916531, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.
Title: CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.
Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
Title: Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
Title: CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
Title: CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
a crucial role of CDK5RAP3 in liver development and hepatic functions, is reported.
Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
Results suggest that C53 might play a role in regulating neuronal proliferation, migration and/or differentiation in embryonic development.
Title: Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MDM2/MDM4 family protein binding	IEA Inferred from Electronic Annotation more info
enables MDM2/MDM4 family protein binding	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables cyclin binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase binding	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-like ligase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin-like protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in apoptotic nuclear changes	ISO Inferred from Sequence Orthology more info
involved_in apoptotic nuclear changes	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in definitive erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic G2/M transition checkpoint	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2/M transition checkpoint	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of MAP kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of reticulophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reticulophagy	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
NOT involved_in positive regulation of ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ufmylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein ufmylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein ufmylation	ISO Inferred from Sequence Orthology more info
involved_in protein ufmylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in rescue of stalled ribosome	IEA Inferred from Electronic Annotation more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome disassembly	ISO Inferred from Sequence Orthology more info
involved_in ribosome disassembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: CDK5 regulatory subunit-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308183.1 → NP_001295112.1 CDK5 regulatory subunit-associated protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AK165494, BM211958, CK625767

UniProtKB/TrEMBL

Q3TSS9

Conserved Domains (1) summary

pfam05600
Location:2 → 389

DUF773; Protein of unknown function (DUF773)
NM_001363255.1 → NP_001350184.1 CDK5 regulatory subunit-associated protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AL596384

UniProtKB/TrEMBL

Q3TSS9

Conserved Domains (1) summary

pfam05600
Location:1 → 453

DUF773; Protein of unknown function (DUF773)
NM_001363256.1 → NP_001350185.1 CDK5 regulatory subunit-associated protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AL596384

UniProtKB/TrEMBL

Q3TSS9

Conserved Domains (1) summary

pfam05600
Location:1 → 453

DUF773; Protein of unknown function (DUF773)
NM_030248.2 → NP_084524.1 CDK5 regulatory subunit-associated protein 3 isoform 1

See identical proteins and their annotated locations for NP_084524.1

Status: VALIDATED

Source sequence(s)

AK149765, BM211958, CK625767

Consensus CDS

CCDS25306.1

UniProtKB/Swiss-Prot

Q3UE41, Q99LM2

UniProtKB/TrEMBL

Q3TLJ5

Related

ENSMUSP00000099441.5, ENSMUST00000103152.11

Conserved Domains (1) summary

pfam05600
Location:5 → 500

DUF773; Protein of unknown function (DUF773)