Cd84 CD84 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd84provided by MGI
Official Full Name: CD84 antigenprovided by MGI
Primary source: MGI:MGI:1336885
See related: Ensembl:ENSMUSG00000038147 AllianceGenome:MGI:1336885
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDw84; SLAMF5; A130013D22Rik
Summary: Predicted to enable identical protein binding activity. Involved in regulation of gene expression; regulation of macrophage activation; and regulation of signal transduction. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in brain; embryo; and testis. Orthologous to human CD84 (CD84 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thymus adult (RPKM 2.1), spleen adult (RPKM 1.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 79.54 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (171667261..171718288)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (171839697..171890718)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis.
Title: CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis.
Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84.
Title: Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84.
CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
Title: CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma.
CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.
Title: CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke.
The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5.
Title: The survival and function of IL-10-producing regulatory B cells are negatively controlled by SLAMF5.
Results show that CD84 expressed on CLL cells interact with CD84 expressed on cells in their microenvironment, inducing cell survival in both sides.
Title: CD84 mediates CLL-microenvironment interactions.
CRISPR-Mediated Slamf1Delta/Delta Slamf5Delta/Delta Slamf6Delta/Delta Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.
Title: CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects.
CD84 is dispensable for thrombus formation and stabilization, indicating that its deficiency may be functionally compensated by other receptors or that it may be important for platelet functions different from platelet-platelet interactions
Title: Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis.
study establishes a central role for germinal center B cell-specific CD84 and Ly108 expression in maintaining B cell tolerance in germinal centers and in preventing autoimmunity
Title: B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance.
results reveal a dual regulation mechanism for platelet CD84 by simultaneous extra- and intracellular cleavage that may modulate platelet-platelet and platelet-immune cell interactions
Title: The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Targeted (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of granulocyte macrophage colony-stimulating factor production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-18 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mast cell degranulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of monocyte chemotactic protein-1 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of lipopolysaccharide-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of macrophage activation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: SLAM family member 5

Names: leukocyte differentiation antigen CD84; signaling lymphocytic activation molecule 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252472.2 → NP_001239401.1 SLAM family member 5 isoform 2 precursor

See identical proteins and their annotated locations for NP_001239401.1

Status: VALIDATED

Source sequence(s)

AC091523, LXEJ02005087

Consensus CDS

CCDS56657.1

UniProtKB/TrEMBL

A0A0R4J1S4

Related

ENSMUSP00000115674.2, ENSMUST00000135386.2

Conserved Domains (1) summary

cd05775
Location:31 → 126

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like
NM_001289470.2 → NP_001276399.1 SLAM family member 5 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC091523, LXEJ02005087

Consensus CDS

CCDS69979.1

UniProtKB/TrEMBL

B7ZMQ1, E9Q9E8

Related

ENSMUSP00000122951.2, ENSMUST00000136479.8

Conserved Domains (2) summary

cd05775
Location:31 → 126

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like

pfam13927
Location:131 → 194

Ig_3; Immunoglobulin domain
NM_013489.4 → NP_038517.1 SLAM family member 5 isoform 1 precursor

See identical proteins and their annotated locations for NP_038517.1

Status: VALIDATED

Source sequence(s)

AC091523, LXEJ02005087

Consensus CDS

CCDS15503.1

UniProtKB/TrEMBL

A0A0R4J0K5, B2RU38

Related

ENSMUSP00000120881.2, ENSMUST00000155802.9

Conserved Domains (2) summary

cd05775
Location:31 → 126

Ig_SLAM-CD84_like_N; N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84_like

pfam13927
Location:131 → 194

Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

171667261..171718288

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036156634.1 → XP_036012527.1 SLAM family member 5 isoform X1

Conserved Domains (2) summary

cd00096
Location:74 → 81

Ig; Ig strand B [structural motif]

cl11960
Location:75 → 133

Ig; Immunoglobulin domain
XM_030244793.2 → XP_030100653.1 SLAM family member 5 isoform X2

Conserved Domains (1) summary

cl11960
Location:26 → 84

Ig; Immunoglobulin domain