Icos inducible T cell co-stimulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Icosprovided by MGI
Official Full Name: inducible T cell co-stimulatorprovided by MGI
Primary source: MGI:MGI:1858745
See related: Ensembl:ENSMUSG00000026009 AllianceGenome:MGI:1858745
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H4; CCLP; AILIM; CRP-1; Ly115
Summary: Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Located in external side of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 1 C2; 1 30.6 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (60999909..61039481)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (60960773..61000322)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Helios[+] and RORgammat[+] Treg populations are differentially regulated by MHCII, CD28, and ICOS to shape the intestinal Treg pool.
Title: Helios(+) and RORγt(+) Treg populations are differentially regulated by MHCII, CD28, and ICOS to shape the intestinal Treg pool.
Icos gene disruption in non-obese diabetic mice elicits myositis associated with anti-troponin T3 autoantibodies.
Title: Icos gene disruption in non-obese diabetic mice elicits myositis associated with anti-troponin T3 autoantibodies.
ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells.
Title: ICOS costimulation is indispensable for the differentiation of T follicular regulatory cells.
PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu.
Title: PD-1 and ICOS counter-regulate tissue resident regulatory T cell development and IL-10 production during flu.
ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation.
Title: ICOS-Deficient Regulatory T Cells Can Prevent Spontaneous Autoimmunity but Are Impaired in Controlling Acute Inflammation.
Immunofibroblasts regulate LTalpha3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction.
Title: Immunofibroblasts regulate LTα3 expression in tertiary lymphoid structures in a pathway dependent on ICOS/ICOSL interaction.
ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection.
Title: ICOS Expression Is Required for Maintenance but Not the Formation of Germinal Centers in the Spleen in Response to Plasmodium yoelii Infection.
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8(+) tissue-resident memory T cells.
Title: Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8(+) tissue-resident memory T cells.
Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
Title: Inducible T-Cell Costimulator Mediates Lymphocyte/Macrophage Interactions During Liver Repair.
An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression.
Title: An Antibody Targeting ICOS Increases Intratumoral Cytotoxic to Regulatory T-cell Ratio and Induces Tumor Regression.

Submit: New GeneRIF Correction See all GeneRIFs (135)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10)
Targeted (13) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Icos (e-PCR), detects polymorphism
- UniSTS:164910

AB023132 (e-PCR)
- UniSTS:163249

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell costimulation	IEA Inferred from Electronic Annotation more info
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in T cell tolerance induction	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell tolerance induction	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inducible T-cell costimulator

Names: CD28 and CTLA-4-like protein; CD28-related protein 1; activation-inducible lymphocyte immunomediatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017480.3 → NP_059508.2 inducible T-cell costimulator precursor

Status: VALIDATED

Source sequence(s)

AL645744

Consensus CDS

CCDS14994.1

UniProtKB/Swiss-Prot

Q9JL17, Q9WVS0

UniProtKB/TrEMBL

A2A6A7, D0E8G6, Q3V3X2, Q5SUZ7

Related

ENSMUSP00000099891.4, ENSMUST00000102827.4

Conserved Domains (1) summary

pfam15910
Location:23 → 135

V-set_2; ICOS V-set domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

60999909..61039481

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496138.3 → XP_006496201.1 inducible T-cell costimulator isoform X1

UniProtKB/Swiss-Prot

Q9JL17, Q9WVS0

UniProtKB/TrEMBL

A2A6A7, D0E8G6, Q3V3X2, Q5SUZ7

Conserved Domains (1) summary

pfam15910
Location:23 → 135

V-set_2; ICOS V-set domain
XM_006496139.3 → XP_006496202.1 inducible T-cell costimulator isoform X1

UniProtKB/Swiss-Prot

Q9JL17, Q9WVS0

UniProtKB/TrEMBL

A2A6A7, D0E8G6, Q3V3X2, Q5SUZ7

Conserved Domains (1) summary

pfam15910
Location:23 → 135

V-set_2; ICOS V-set domain
XM_006496140.1 → XP_006496203.1 inducible T-cell costimulator isoform X2

UniProtKB/TrEMBL

A2A6A7

Conserved Domains (1) summary

pfam15910
Location:1 → 106

V-set_2; ICOS V-set domain