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    Clybl citrate lyase beta like [ Mus musculus (house mouse) ]

    Gene ID: 69634, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Clyblprovided by MGI
    Official Full Name
    citrate lyase beta likeprovided by MGI
    Primary source
    MGI:MGI:1916884
    See related
    Ensembl:ENSMUSG00000025545 AllianceGenome:MGI:1916884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clb; 0610033J05Rik; 2310014M14Rik
    Summary
    Enables (S)-citramalyl-CoA lyase activity. Involved in positive regulation of cobalamin metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CLYBL (citramalyl-CoA lyase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in kidney adult (RPKM 9.1), heart adult (RPKM 8.2) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Clybl in Genome Data Viewer
    Location:
    14 E5; 14 65.86 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122408289..122639646)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122170994..122402234)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transmembrane 9 superfamily member 2 Neighboring gene STARR-seq mESC enhancer starr_37749 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene RIKEN cDNA 1700108J01 gene Neighboring gene STARR-seq mESC enhancer starr_37753 Neighboring gene STARR-seq mESC enhancer starr_37767 Neighboring gene predicted gene 5089 Neighboring gene STARR-seq mESC enhancer starr_37772 Neighboring gene predicted gene, 25464 Neighboring gene STARR-seq mESC enhancer starr_37773 Neighboring gene STARR-seq mESC enhancer starr_37776 Neighboring gene predicted gene, 53847 Neighboring gene zinc finger protein of the cerebellum 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of novel mouse and human putative citrate lyase beta-subunit. Morikawa J, et al. Biochem Biophys Res Commun, 2001 Dec 21. PMID 11741334
    2. Itaconate alleviates diet-induced obesity via activation of brown adipocyte thermogenesis. Yu Z, et al. Cell Rep, 2024 May 28. PMID 38691458
    3. The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B(12). Shen H, et al. Cell, 2017 Nov 2. PMID 29056341, Free PMC Article
    4. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    5. Chemical Crosslinking Mass Spectrometry Analysis of Protein Conformations and Supercomplexes in Heart Tissue. Chavez JD, et al. Cell Syst, 2018 Jan 24. PMID 29199018, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (S)-citramalyl-CoA lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables (S)-citramalyl-CoA lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables (S)-citramalyl-CoA lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables malate synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cobalamin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotrimerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cobalamin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cobalamin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cobalamin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    citramalyl-CoA lyase, mitochondrial
    Names
    (3S)-malyl-CoA thioesterase
    beta-methylmalate synthase
    citrate lyase subunit beta-like protein, mitochondrial
    malate synthase
    NP_083832.2
    XP_030103854.1
    XP_030103856.1
    XP_030103857.1
    XP_036014733.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029556.3 → NP_083832.2  citramalyl-CoA lyase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_083832.2

      Status: VALIDATED

      Source sequence(s)
      AC164315, AK009345, CX202248
      Consensus CDS
      CCDS27346.1
      UniProtKB/Swiss-Prot
      Q8R4N0, Q9D7D0
      Related
      ENSMUSP00000026625.6, ENSMUST00000026625.7
      Conserved Domains (1) summary
      COG2301
      Location:45 → 335
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      122408289..122639646
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158840.1 → XP_036014733.1  citramalyl-CoA lyase, mitochondrial isoform X1

    2. XM_030247994.1 → XP_030103854.1  citramalyl-CoA lyase, mitochondrial isoform X2

      Conserved Domains (1) summary
      COG2301
      Location:1 → 204
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

    3. XM_030247997.2 → XP_030103857.1  citramalyl-CoA lyase, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG2301
      Location:1 → 174
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]

    4. XM_030247996.1 → XP_030103856.1  citramalyl-CoA lyase, mitochondrial isoform X3

      Conserved Domains (1) summary
      COG2301
      Location:1 → 174
      CitE; Citrate lyase beta subunit [Carbohydrate transport and metabolism]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R4N0.2 GenPept UniProtKB/Swiss-Prot:Q8R4N0

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