Has3 hyaluronan synthase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Has3provided by MGI
Official Full Name: hyaluronan synthase 3provided by MGI
Primary source: MGI:MGI:109599
See related: Ensembl:ENSMUSG00000031910 AllianceGenome:MGI:109599
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables hyaluronan synthase activity. Involved in extracellular matrix assembly; extracellular polysaccharide biosynthetic process; and hyaluronan biosynthetic process. Located in cytoplasm and nucleus. Is active in plasma membrane. Is expressed in several structures, including central nervous system; genitourinary system; jaw; sensory organ; and skin. Orthologous to human HAS3 (hyaluronan synthase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 2.9), whole brain E14.5 (RPKM 2.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.28 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (107596874..107609534)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (106870242..106882902)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3.
Title: CPAP-induced airway hyper-reactivity in mice is modulated by hyaluronan synthase-3.
Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
Title: Hyaluronan synthase 3 is protective after cardiac ischemia-reperfusion by preserving the T cell response.
SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.
Title: SMC-Derived Hyaluronan Modulates Vascular SMC Phenotype in Murine Atherosclerosis.
hyaluronan metabolism via HAS3 does not markedly influence the extracellular matrix structure or function of the Achilles tendon body
Title: Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa.
These gene expression patterns suggested that Has3 is the main control factor for prenatal and postnatal HA synthesis of the tooth germ, and may in part regulate crown and root formation of the tooth germ, maintenance of stem cell niches in the apical bud as well as mineral transport in PL.
Title: An in situ hybridization study of Hyaluronan synthase (Has) mRNA in developing mouse molar and incisor tooth germs.
HAS3-mediated HA synthesis after vessel injury supports seminal signaling pathways in activation of VSMC, increases platelet-derived growth factor BB-mediated migration, and in turn enhances neointimal hyperplasia in vivo.
Title: Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.
This study demonstrates that the ablation of Has3-dependent HA causes reduced ECS volume in the CA1 stratum pyramidale, epileptiform activity in the CA1 region, and epileptic seizures in the mutant mouse.
Title: Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space.
Selective loss of Has1 and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.
Title: Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.
proper regulation of the expression of each HAS isoform is required for optimal malignant transformation and tumor growth
Title: Selective expression and functional characteristics of three mammalian hyaluronan synthases in oncogenic malignant transformation.
expression in the developing teeth, vibrissae hair follicles, nasal cavity, and inner ear
Title: Three vertebrate hyaluronan synthases are expressed during mouse development in distinct spatial and temporal patterns.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hyaluronan synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hyaluronan synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables hyaluronan synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in extracellular matrix assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hyaluronan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in hyaluronan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hyaluronan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in polysaccharide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polysaccharide biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hyaluranon cable assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hyaluranon cable assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in hyaluranon cable	IEA Inferred from Electronic Annotation more info
located_in hyaluranon cable	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hyaluronan synthase 3

Names: HA synthase 3; hyaluronate synthase 3; hyaluronic acid synthase 3

NP_001317977.1

EC 2.4.1.212

NP_032243.2

EC 2.4.1.212

XP_006530763.1

EC 2.4.1.212

XP_006530764.1

EC 2.4.1.212

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001331048.1 → NP_001317977.1 hyaluronan synthase 3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC123864, AK028582

Consensus CDS

CCDS22640.1

UniProtKB/Swiss-Prot

O08650, Q8CEB9

UniProtKB/TrEMBL

B2RR08

Related

ENSMUSP00000135303.2, ENSMUST00000176144.8

Conserved Domains (2) summary

cd06434
Location:87 → 365

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

cl01224
Location:403 → 493

DUF805; Protein of unknown function (DUF805)
NM_008217.4 → NP_032243.2 hyaluronan synthase 3

See identical proteins and their annotated locations for NP_032243.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC140328, AK028582, BY132822

Consensus CDS

CCDS22640.1

UniProtKB/Swiss-Prot

O08650, Q8CEB9

UniProtKB/TrEMBL

B2RR08

Related

ENSMUSP00000034385.6, ENSMUST00000034385.12

Conserved Domains (2) summary

cd06434
Location:87 → 365

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

cl01224
Location:403 → 493

DUF805; Protein of unknown function (DUF805)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

107596874..107609534

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006530701.4 → XP_006530764.1 hyaluronan synthase 3 isoform X1

See identical proteins and their annotated locations for XP_006530764.1

UniProtKB/Swiss-Prot

O08650, Q8CEB9

UniProtKB/TrEMBL

B2RR08

Conserved Domains (2) summary

cd06434
Location:87 → 365

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

cl01224
Location:403 → 493

DUF805; Protein of unknown function (DUF805)
XM_006530700.4 → XP_006530763.1 hyaluronan synthase 3 isoform X1

See identical proteins and their annotated locations for XP_006530763.1

UniProtKB/Swiss-Prot

O08650, Q8CEB9

UniProtKB/TrEMBL

B2RR08

Conserved Domains (2) summary

cd06434
Location:87 → 365

GT2_HAS; Hyaluronan synthases catalyze polymerization of hyaluronan

cl01224
Location:403 → 493

DUF805; Protein of unknown function (DUF805)