Abcf1 ATP-binding cassette, sub-family F member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcf1provided by MGI
Official Full Name: ATP-binding cassette, sub-family F member 1provided by MGI
Primary source: MGI:MGI:1351658
See related: Ensembl:ENSMUSG00000038762 AllianceGenome:MGI:1351658
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abc50; GCN20; D17Wsu166e
Summary: Predicted to enable ATP binding activity; ribosome binding activity; and translation activator activity. Predicted to be involved in positive regulation of translation and translational initiation. Predicted to be located in cytosol; nucleus; and ribosome. Is expressed in several structures, including eye; genitourinary system; hemolymphoid system; lung; and nervous system. Orthologous to human ABCF1 (ATP binding cassette subfamily F member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 41.9), CNS E11.5 (RPKM 33.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 B1; 17 18.8 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (36267711..36280642, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (35956819..35969750, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCF1, an ATP-Binding Cassette (ABC) family member protein, which possesses an E2 ubiquitin enzyme activity, through which it controls the Lipopolysaccharide (LPS)- Toll-like Receptor-4 (TLR4) mediated gram-negative insult by targeting key proteins for K63-polyubiquitination.
Title: The ATP-Binding Cassette Gene ABCF1 Functions as an E2 Ubiquitin-Conjugating Enzyme Controlling Macrophage Polarization to Dampen Lethal Septic Shock.
Abcf1 expression in embryos is required for development
Title: The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development.
Six putative caspase substrates, including five novel proteins (ABCF1, AKAP1, CPE, DOPEY1 and GOPC1) that may be targeted specifically by the initiator caspases 8 and 10 during the early stages of apoptosis, were identified.[caspase 10]
Title: Genome-wide screening and identification of novel proteolytic cleavage targets of caspase-8 and -10 in vitro.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D17Wsu166e (e-PCR), detects polymorphism
- UniSTS:142174

AU041969 (e-PCR)
- UniSTS:160656

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISS Inferred from Sequence or Structural Similarity more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ribosome binding	ISO Inferred from Sequence Orthology more info
enables ribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables translation activator activity	ISO Inferred from Sequence Orthology more info
enables translation activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in positive regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
NOT involved_in ribosome biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in translational initiation	ISO Inferred from Sequence Orthology more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in ribosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family F member 1

Names: ATP-binding cassette, sub-family F (GCN20), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013854.1 → NP_038882.1 ATP-binding cassette sub-family F member 1

Status: VALIDATED

Source sequence(s)

BC063094

Consensus CDS

CCDS28713.1

UniProtKB/Swiss-Prot

Q6NV71, Q6P542

UniProtKB/TrEMBL

Q5RL55

Related

ENSMUSP00000036881.9, ENSMUST00000043757.15

Conserved Domains (2) summary

cd03221
Location:296 → 517

ABCF_EF-3; ATP-binding cassette domain of elongation factor 3, subfamily F

COG0488
Location:294 → 825

Uup; ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]