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    Tdo2 tryptophan 2,3-dioxygenase [ Mus musculus (house mouse) ]

    Gene ID: 56720, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tdo2provided by MGI
    Official Full Name
    tryptophan 2,3-dioxygenaseprovided by MGI
    Primary source
    MGI:MGI:1928486
    See related
    Ensembl:ENSMUSG00000028011 AllianceGenome:MGI:1928486
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TO; TDO; chky
    Summary
    Predicted to enable several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Predicted to be involved in aromatic amino acid metabolic process and protein homotetramerization. Is expressed in cerebellum; liver; male reproductive gland or organ; and small intestine. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward liver adult (RPKM 173.8) See more
    Orthologs
    NEW
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    Genomic context

    See Tdo2 in Genome Data Viewer
    Location:
    3 E3; 3 35.97 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (81865719..81883035, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (81958412..81975728, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102640985 Neighboring gene predicted gene, 22531 Neighboring gene STARR-seq mESC enhancer starr_08032 Neighboring gene STARR-positive B cell enhancer ABC_E3439 Neighboring gene STARR-positive B cell enhancer ABC_E10186 Neighboring gene cathepsin O Neighboring gene acid-sensing ion channel family member 5 Neighboring gene guanylate cyclase 1, soluble, beta 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amino acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxygen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tryptophan 2,3-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables tryptophan 2,3-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to nitroglycerin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tryptophan catabolic process to acetyl-CoA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tryptophan catabolic process to acetyl-CoA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tryptophan catabolic process to acetyl-CoA ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tryptophan catabolic process to kynurenine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tryptophan catabolic process to kynurenine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tryptophan metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tryptophan metabolic process ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tryptophan 2,3-dioxygenase
    Names
    TRPO
    tdo variant1
    tdo variant2
    tryptamin 2,3-dioxygenase
    tryptophan oxygenase
    tryptophan pyrrolase
    tryptophanase
    NP_064295.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019911.2NP_064295.2  tryptophan 2,3-dioxygenase

      See identical proteins and their annotated locations for NP_064295.2

      Status: PROVISIONAL

      Source sequence(s)
      BC018390
      Consensus CDS
      CCDS17427.1
      UniProtKB/Swiss-Prot
      P48776
      UniProtKB/TrEMBL
      C5NSA7, Q8VCW3
      Related
      ENSMUSP00000029645.9, ENSMUST00000029645.14
      Conserved Domains (1) summary
      pfam03301
      Location:26372
      Trp_dioxygenase; Tryptophan 2,3-dioxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      81865719..81883035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)