Coq5 coenzyme Q5 methyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Coq5provided by MGI
Official Full Name: coenzyme Q5 methyltransferaseprovided by MGI
Primary source: MGI:MGI:1098643
See related: Ensembl:ENSMUSG00000041733 AllianceGenome:MGI:1098643
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D5Ertd33e; 1810014G04Rik
Summary: Predicted to enable 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity. Predicted to be involved in methylation and ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in heart and heart right ventricle. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 9. Orthologous to human COQ5 (coenzyme Q5, methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 22.2), cerebellum adult (RPKM 9.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 56.03 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (115417752..115435029)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (115279666..115296974)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

RH126024 (e-PCR)
- UniSTS:162736

D9Mgc42e (e-PCR), detects polymorphism
- UniSTS:142784

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquinone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquinone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquinone biosynthetic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in extrinsic component of mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ubiquinone biosynthesis complex	IEA Inferred from Electronic Annotation more info
part_of ubiquinone biosynthesis complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

Names: coenzyme Q5 homolog, methyltransferase; ubiquinone biosynthesis methyltransferase COQ5, mitochondrial

NP_080780.1

EC 2.1.1.201

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026504.3 → NP_080780.1 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial precursor

See identical proteins and their annotated locations for NP_080780.1

Status: VALIDATED

Source sequence(s)

AC145070

Consensus CDS

CCDS19585.1

UniProtKB/Swiss-Prot

Q9CXI0, Q9D6Y6, Q9D900

Related

ENSMUSP00000048001.5, ENSMUST00000040421.11

Conserved Domains (1) summary

PRK00216
Location:56 → 327

ubiE; ubiquinone/menaquinone biosynthesis methyltransferase; Reviewed