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    Cyb561d2 cytochrome b561 family, member D2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cyb561d2provided by RGD
    Official Full Name
    cytochrome b561 family, member D2provided by RGD
    Primary source
    RGD:1359644
    See related
    EnsemblRapid:ENSRNOG00000021887 AllianceGenome:RGD:1359644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable heme binding activity; transmembrane ascorbate ferrireductase activity; and transmembrane monodehydroascorbate reductase activity. Predicted to be involved in ascorbate homeostasis. Predicted to be located in vesicle. Predicted to be active in endoplasmic reticulum. Orthologous to human CYB561D2 (cytochrome b561 family member D2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 65.8), Brain (RPKM 61.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cyb561d2 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117091844..117094434, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108213201..108215778, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116295328..116297879, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene uncharacterized LOC120094259 Neighboring gene transmembrane protein 115 Neighboring gene NPR2-like, GATOR1 complex subunit Neighboring gene zinc finger, MYND-type containing 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Spectral characterization of the recombinant mouse tumor suppressor 101F6 protein. Bérczi A, et al. Eur Biophys J, 2010 Jul. PMID 19943161
    2. Involvement of 101F6, a homologue of cytochrome b561, in the reduction of ferric ions. Mizutani A, et al. J Biochem, 2007 Dec. PMID 17938141
    3. Functional expression and characterization of human 101F6 protein, a homologue of cytochrome b561 and a candidate tumor suppressor gene product. Recuenco MC, et al. Biofactors, 2008. PMID 19734123
    4. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. Lerman MI, et al. Cancer Res, 2000 Nov 1. PMID 11085536
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC95239

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane ascorbate ferrireductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transmembrane monodehydroascorbate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane monodehydroascorbate reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane monodehydroascorbate reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ascorbate homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ascorbate homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane reductase CYB561D2
    Names
    cytochrome b-561 domain containing 2
    cytochrome b561 domain-containing protein 2
    putative tumor suppressor protein 101F6
    transmembrane ascorbate ferrireductase
    NP_001007754.1
    XP_006243866.1
    XP_038937724.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007753.2 → NP_001007754.1  transmembrane reductase CYB561D2

      See identical proteins and their annotated locations for NP_001007754.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q641Y1
      UniProtKB/TrEMBL
      A0A8L2QHT3, A6I2X3
      Related
      ENSRNOP00000071082.1, ENSRNOT00000082320.3
      Conserved Domains (1) summary
      cd08761
      Location:25 → 205
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    2. NM_001434351.1 → NP_001421280.1  transmembrane reductase CYB561D2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q641Y1
      UniProtKB/TrEMBL
      A0A8L2QHT3, A6I2X3

    3. NM_001434352.1 → NP_001421281.1  transmembrane reductase CYB561D2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q641Y1
      UniProtKB/TrEMBL
      A0A8L2QHT3, A6I2X3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117091844..117094434 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243804.5 → XP_006243866.1  transmembrane reductase CYB561D2 isoform X1

      Conserved Domains (1) summary
      cd08761
      Location:25 → 205
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product

    2. XM_039081796.2 → XP_038937724.1  transmembrane reductase CYB561D2 isoform X1

      Conserved Domains (1) summary
      cd08761
      Location:25 → 205
      Cyt_b561_CYB561D2_like; Eukaryotic cytochrome b(561), including the CYB561D2 gene product
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q641Y1.1 GenPept UniProtKB/Swiss-Prot:Q641Y1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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