Sar1a secretion associated, Ras related GTPase 1A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sar1aprovided by RGD
Official Full Name: secretion associated, Ras related GTPase 1Aprovided by RGD
Primary source: RGD:1359540
See related: EnsemblRapid:ENSRNOG00000000557 AllianceGenome:RGD:1359540
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sara1
Summary: Predicted to enable G protein activity; amino acid sensor activity; and inorganic diphosphate phosphatase activity. Predicted to be involved in several processes, including COPII-coated vesicle budding; cellular response to leucine starvation; and negative regulation of TORC1 signaling. Predicted to act upstream of or within negative regulation of cargo loading into COPII-coated vesicle and vesicle-mediated transport. Predicted to be located in Golgi apparatus and sarcoplasmic reticulum. Predicted to be part of COPII vesicle coat. Predicted to be active in endoplasmic reticulum exit site and lysosomal membrane. Orthologous to several human genes including PPA1 (inorganic pyrophosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 470.6), Lung (RPKM 464.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30166310..30178718)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (29623529..29635935)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31298269..31310676)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sar1 recruitment to the endoplasmic reticulum-membrane is sensitive to H89-sensitive kinase activation, indicating the first step in transport vesicle formation occurs under kinase regulation
Title: Sar1 translocation onto the ER-membrane for vesicle budding has different pathways for promotion and suppression of ER-to-Golgi transport mediated through H89-sensitive kinase and ER-resident G protein.
beta-tubulin is one of downstream effectors of H89-sensitive kinase and suppression of endoplasmic reticulum (ER)-coupled beta-tubulin phosphorylation decreases Sar1 translocation onto the ER.
Title: H89 sensitive kinase regulates the translocation of Sar1 onto the ER membrane through phosphorylation of ER-coupled β-tubulin.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH80472 (e-PCR)
- UniSTS:86099

RH127573 (e-PCR)
- UniSTS:210883

SAR1A (e-PCR)
- UniSTS:503011

MARC_21359-21360:1023909782:1 (e-PCR)
- UniSTS:268541

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables amino acid sensor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in COPII vesicle coating	ISO Inferred from Sequence Orthology more info
involved_in COPII-coated vesicle cargo loading	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to leucine starvation	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
NOT involved_in lipoprotein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cargo loading into COPII-coated vesicle	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cargo loading into COPII-coated vesicle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of COPII vesicle coat	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum exit site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding protein SAR1a

Names: SAR1 gene homolog A; SAR1 homolog A; SAR1a gene homolog 1

NP_001007740.1

EC 3.6.5.2

XP_006256512.1

EC 3.6.5.2

XP_006256513.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.