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    Dock3 dedicator of cyto-kinesis 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315992, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dock3provided by RGD
    Official Full Name
    dedicator of cyto-kinesis 3provided by RGD
    Primary source
    RGD:1306677
    See related
    EnsemblRapid:ENSRNOG00000014576 AllianceGenome:RGD:1306677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in small GTPase-mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 196.3), Testes (RPKM 66.9) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dock3 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    61
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (116431158..116782218, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107552462..107903527, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115627282..115982260, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte-derived neurotrophic factor Neighboring gene uncharacterized LOC134480229 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene bleomycin hydrolase, pseudogene 1 Neighboring gene MAPK activated protein kinase 3 Neighboring gene ribosomal protein SA, pseudogene 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Modifier of cell adhesion regulates N-cadherin-mediated cell-cell adhesion and neurite outgrowth. Chen Q, et al. J Neurosci, 2005 Jan 12. PMID 15647471, Free PMC Article
    2. Dock3 Participate in Epileptogenesis Through rac1 Pathway in Animal Models. Li J, et al. Mol Neurobiol, 2016 May. PMID 26319681
    3. Disruption of a novel member of a sodium/hydrogen exchanger family and DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype. de Silva MG, et al. J Med Genet, 2003 Oct. PMID 14569117, Free PMC Article
    4. A novel mechanism for the regulation of amyloid precursor protein metabolism. Chen Q, et al. J Cell Biol, 2002 Jul 8. PMID 12093789, Free PMC Article
    5. Dock3 regulates BDNF-TrkB signaling for neurite outgrowth by forming a ternary complex with Elmo and RhoG. Namekata K, et al. Genes Cells, 2012 Aug. PMID 22734669

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dedicator of cytokinesis protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108184.2 → NP_001101654.2  dedicator of cytokinesis protein 3

      Status: VALIDATED

      Source sequence(s)
      AI070118, JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZM58, A0A8I6GLI7
      Related
      ENSRNOP00000095224.1, ENSRNOT00000112624.2
      Conserved Domains (4) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      116431158..116782218 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243867.5 → XP_006243929.1  dedicator of cytokinesis protein 3 isoform X11

      See identical proteins and their annotated locations for XP_006243929.1

      UniProtKB/TrEMBL
      A0A8I5ZM58, A0A8I5ZZP1
      Related
      ENSRNOP00000085218.2, ENSRNOT00000109918.2
      Conserved Domains (5) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1226 → 1617
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam02158
      Location:1777 → 1898
      Neuregulin; Neuregulin family
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    2. XM_006243865.5 → XP_006243927.1  dedicator of cytokinesis protein 3 isoform X2

      See identical proteins and their annotated locations for XP_006243927.1

      UniProtKB/TrEMBL
      A0A8I5ZM58, F1M4N6
      Related
      ENSRNOP00000019867.7, ENSRNOT00000019867.9
      Conserved Domains (5) summary
      cd08695
      Location:420 → 609
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1235 → 1626
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam02158
      Location:1786 → 1907
      Neuregulin; Neuregulin family
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    3. XM_039081583.2 → XP_038937511.1  dedicator of cytokinesis protein 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (5) summary
      cd08695
      Location:426 → 615
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1227 → 1618
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam03154
      Location:1743 → 2050
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    4. XM_039081582.2 → XP_038937510.1  dedicator of cytokinesis protein 3 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (5) summary
      cd08695
      Location:426 → 615
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1232 → 1623
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam03154
      Location:1748 → 2055
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    5. XM_063265626.1 → XP_063121696.1  dedicator of cytokinesis protein 3 isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZM58

    6. XM_039081581.2 → XP_038937509.1  dedicator of cytokinesis protein 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (5) summary
      cd08695
      Location:426 → 615
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1241 → 1632
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam03154
      Location:1757 → 2058
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    7. XM_063265625.1 → XP_063121695.1  dedicator of cytokinesis protein 3 isoform X8

      UniProtKB/TrEMBL
      A0A8I5ZM58

    8. XM_039081584.2 → XP_038937512.1  dedicator of cytokinesis protein 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (4) summary
      cd08695
      Location:426 → 615
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1241 → 1632
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    9. XM_039081580.2 → XP_038937508.1  dedicator of cytokinesis protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (5) summary
      cd08695
      Location:426 → 615
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1241 → 1632
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      cd12048
      Location:10 → 65
      SH3_DOCK3_B; Src Homology 3 domain of Class B Dedicator of Cytokinesis 3
      pfam03154
      Location:1757 → 2064
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:69 → 412
      DOCK_N; DOCK N-terminus

    10. XM_063265621.1 → XP_063121691.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZM58

    11. XM_039081586.2 → XP_038937514.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (4) summary
      cd08695
      Location:308 → 497
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1123 → 1514
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      pfam03154
      Location:1639 → 1946
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:1 → 294
      DOCK_N; DOCK N-terminus

    12. XM_063265620.1 → XP_063121690.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZM58

    13. XM_039081585.2 → XP_038937513.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Conserved Domains (4) summary
      cd08695
      Location:308 → 497
      C2_Dock-B; C2 domains found in Dedicator Of CytoKinesis (Dock) class B proteins
      cd11704
      Location:1123 → 1514
      DHR2_DOCK3; Dock Homology Region 2, a GEF domain, of Class B Dedicator of Cytokinesis 3
      pfam03154
      Location:1639 → 1946
      Atrophin-1; Atrophin-1 family
      pfam16172
      Location:1 → 294
      DOCK_N; DOCK N-terminus

    14. XM_063265622.1 → XP_063121692.1  dedicator of cytokinesis protein 3 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZM58
      Related
      ENSRNOP00000079156.2, ENSRNOT00000096313.2

    15. XM_039081587.2 → XP_038937515.1  dedicator of cytokinesis protein 3 isoform X10

      Conserved Domains (2) summary
      pfam03154
      Location:970 → 1277
      Atrophin-1; Atrophin-1 family
      cl06123
      Location:454 → 845
      DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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