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    Zic4 Zic family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315882, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zic4provided by RGD
    Official Full Name
    Zic family member 4provided by RGD
    Primary source
    RGD:1307298
    See related
    EnsemblRapid:ENSRNOG00000014871 AllianceGenome:RGD:1307298
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZIC4 (Zic family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 26.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zic4 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (100795860..100816276)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (91916356..91936525)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (98755104..98760737)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 1 Neighboring gene uncharacterized LOC134479983 Neighboring gene transfer RNA alanine (anticodon AGC) 58 Neighboring gene Zic family member 1 Neighboring gene transcriptional adaptor 3, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family. Ishiguro A, et al. Biochem Biophys Res Commun, 2004 Nov 5. PMID 15465018
    2. CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA. Sakai-Kato K, et al. Biochim Biophys Acta, 2008 Jul-Aug. PMID 18298960
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein ZIC 4
    Names
    zinc finger protein of the cerebellum 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394128.1 → NP_001381057.1  zinc finger protein ZIC 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I228, A6I233, D4A6Z4
      Related
      ENSRNOP00000019938.6, ENSRNOT00000019938.9
      Conserved Domains (3) summary
      COG5048
      Location:131 → 288
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:178 → 198
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam18366
      Location:122 → 166
      zf_ZIC; Zic proteins zinc finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      100795860..100816276
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265570.1 → XP_063121640.1  zinc finger protein ZIC 4 isoform X3

      UniProtKB/TrEMBL
      A6I233
      Related
      ENSRNOP00000097909.2, ENSRNOT00000100286.2

    2. XM_063265569.1 → XP_063121639.1  zinc finger protein ZIC 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ATI6, A6I233

    3. XM_063265568.1 → XP_063121638.1  zinc finger protein ZIC 4 isoform X1

      UniProtKB/TrEMBL
      A6I233, A6I234

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108176.1: Suppressed sequence

      Description
      NM_001108176.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

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