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    Usp34 ubiquitin specific peptidase 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360990, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Usp34provided by RGD
    Official Full Name
    ubiquitin specific peptidase 34provided by RGD
    Primary source
    RGD:1565181
    See related
    EnsemblRapid:ENSRNOG00000051889 AllianceGenome:RGD:1565181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cysteine-type deubiquitinase activity and cysteine-type endopeptidase activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway; protein K48-linked deubiquitination; and regulation of protein stability. Predicted to be active in cytosol and nucleus. Orthologous to human USP34 (ubiquitin specific peptidase 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 276.9), Brain (RPKM 239.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Usp34 in Genome Data Viewer
    Location:
    14q22
    Exon count:
    81
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (101487110..101677519)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (97285799..97476376)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (108060653..108264706)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene exportin 1 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene telomerase RNA component interacting Rnase like 1 Neighboring gene uncharacterized LOC108352815 Neighboring gene similar to human chromosome 2 open reading frame 74 Neighboring gene activator of HSP90 ATPase homolog 2 Neighboring gene deoxycytidine kinase, pseudogene 1 Neighboring gene SANT and BTB domain regulator of CSR

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling. Lui TT, et al. Mol Cell Biol, 2011 May. PMID 21383061, Free PMC Article
    2. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Quesada V, et al. Biochem Biophys Res Commun, 2004 Jan 30. PMID 14715245
    3. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 34
    Names
    ubiquitin specific protease 34
    NP_001258125.1
    XP_038948159.1
    XP_038948160.1
    XP_038948161.1
    XP_038948162.1
    XP_063129477.1
    XP_063129478.1
    XP_063129479.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271196.2 → NP_001258125.1  ubiquitin carboxyl-terminal hydrolase 34

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I5ZVK3, A0A8I6GH56
      Related
      ENSRNOP00000081701.1, ENSRNOT00000110345.2
      Conserved Domains (2) summary
      cd02659
      Location:1933 → 2282
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam00443
      Location:1935 → 2277
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      101487110..101677519
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092231.2 → XP_038948159.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GH56
      Conserved Domains (2) summary
      cd02659
      Location:1934 → 2283
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:2401 → 2734
      DUF3517; Domain of unknown function (DUF3517)

    2. XM_039092233.2 → XP_038948161.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GH56
      Related
      ENSRNOP00000088502.1, ENSRNOT00000110300.2
      Conserved Domains (2) summary
      cd02659
      Location:1934 → 2283
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:2401 → 2734
      DUF3517; Domain of unknown function (DUF3517)

    3. XM_039092232.2 → XP_038948160.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GH56
      Conserved Domains (2) summary
      cd02659
      Location:1922 → 2271
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:2389 → 2722
      DUF3517; Domain of unknown function (DUF3517)

    4. XM_063273407.1 → XP_063129477.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZT30, A0A8I6GH56
      Related
      ENSRNOP00000081582.2, ENSRNOT00000094041.2

    5. XM_063273409.1 → XP_063129479.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X7

      UniProtKB/TrEMBL
      A0A8I6GH56

    6. XM_039092234.2 → XP_038948162.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X5

      UniProtKB/TrEMBL
      A6JQ71
      Conserved Domains (2) summary
      cd02659
      Location:1735 → 2084
      peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam12030
      Location:2202 → 2535
      DUF3517; Domain of unknown function (DUF3517)

    7. XM_063273408.1 → XP_063129478.1  ubiquitin carboxyl-terminal hydrolase 34 isoform X6

      UniProtKB/TrEMBL
      A6JQ71
    Nucleotide Protein Strain
    Heading Accession and Version

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