Pofut2 protein O-fucosyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pofut2provided by RGD
Official Full Name: protein O-fucosyltransferase 2provided by RGD
Primary source: RGD:1307334
See related: EnsemblRapid:ENSRNOG00000001228 AllianceGenome:RGD:1307334
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable peptide-O-fucosyltransferase activity. Predicted to be involved in positive regulation of protein folding; protein O-linked fucosylation; and regulation of secretion. Predicted to act upstream of or within several processes, including fucosylation; mesoderm formation; and regulation of epithelial to mesenchymal transition. Predicted to be located in Golgi apparatus. Orthologous to human POFUT2 (protein O-fucosyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 141.2), Kidney (RPKM 91.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (11366636..11378252, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (11367073..11377788, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (12117811..12128747, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

2310011G23Rik (e-PCR), detects polymorphism
- UniSTS:259021

RH134530 (e-PCR)
- UniSTS:217810

RH129685 (e-PCR)
- UniSTS:212982

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables fucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables peptide-O-fucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-O-fucosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fucose metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fucosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesoderm formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked fucosylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GDP-fucose protein O-fucosyltransferase 2

NP_001101091.2

EC 2.4.1.221

XP_063135227.1

EC 2.4.1.221

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.