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    Kiaa1549 KIAA1549 homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312246, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kiaa1549provided by RGD
    Official Full Name
    KIAA1549 homologprovided by RGD
    Primary source
    RGD:1306271
    See related
    EnsemblRapid:ENSRNOG00000013729 AllianceGenome:RGD:1306271
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306271
    Summary
    Predicted to be located in photoreceptor connecting cilium. Human ortholog(s) of this gene implicated in retinitis pigmentosa 86. Orthologous to human KIAA1549 (KIAA1549). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 41.2), Kidney (RPKM 30.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kiaa1549 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (67807635..67935303, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (66840674..66968407, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (65834933..65962722, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene high-mobility group box 1, pseudogene 18 Neighboring gene SVOP like Neighboring gene ATPase H+ transporting V0 subunit a4 Neighboring gene uncharacterized LOC134486756 Neighboring gene transmembrane protein 213 Neighboring gene ZC3HAV1 like Neighboring gene zinc finger CCCH-type containing, antiviral 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Homozygous variants in KIAA1549, encoding a ciliary protein, are associated with autosomal recessive retinitis pigmentosa. de Bruijn SE, et al. J Med Genet, 2018 Oct. PMID 30120214

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in photoreceptor connecting cilium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    UPF0606 protein KIAA1549 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      67807635..67935303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286936.1 → XP_063143006.1  UPF0606 protein KIAA1549 homolog isoform X4

      UniProtKB/TrEMBL
      D3Z9D0

    2. XM_063286933.1 → XP_063143003.1  UPF0606 protein KIAA1549 homolog isoform X2

      UniProtKB/TrEMBL
      D3Z9D0

    3. XM_063286934.1 → XP_063143004.1  UPF0606 protein KIAA1549 homolog isoform X3

      UniProtKB/TrEMBL
      D3Z9D0

    4. XM_231616.10 → XP_231616.5  UPF0606 protein KIAA1549 homolog isoform X1

      See identical proteins and their annotated locations for XP_231616.5

      UniProtKB/TrEMBL
      D3Z9D0
      Related
      ENSRNOP00000050121.7, ENSRNOT00000040391.7
      Conserved Domains (1) summary
      pfam12877
      Location:1023 → 1688
      DUF3827; Domain of unknown function (DUF3827)

    5. XM_063286937.1 → XP_063143007.1  UPF0606 protein KIAA1549 homolog isoform X5

      UniProtKB/TrEMBL
      D3Z9D0
      Related
      ENSRNOP00000112386.1, ENSRNOT00000139757.1
    Nucleotide Protein Strain
    Heading Accession and Version

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