Racgap1 Rac GTPase-activating protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Racgap1provided by RGD
Full Name: Rac GTPase-activating protein 1provided by RGD
Primary source: RGD:1305912
See related: EnsemblRapid:ENSRNOG00000049033 AllianceGenome:RGD:1305912
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including GTPase activator activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and tubulin binding activity. Predicted to be involved in several processes, including cytoskeleton-dependent cytokinesis; mitotic spindle midzone assembly; and regulation of cell cycle process. Predicted to be located in several cellular components, including cytoplasmic side of plasma membrane; mitotic spindle; and nucleoplasm. Predicted to be part of centralspindlin complex. Predicted to be active in several cellular components, including cleavage furrow; midbody; and spindle midzone. Human ortholog(s) of this gene implicated in congenital dyserythropoietic anemia. Orthologous to human RACGAP1 (Rac GTPase activating protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 167.6), Spleen (RPKM 104.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (132629789..132659738, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (130750936..130780891, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (141277303..141308849, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH131552 (e-PCR)
- UniSTS:214835

RH128358 (e-PCR)
- UniSTS:211666

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables gamma-tubulin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring assembly	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in sulfate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of centralspindlin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of centralspindlin complex	ISO Inferred from Sequence Orthology more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in spindle	ISO Inferred from Sequence Orthology more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rac GTPase-activating protein 1

Names: rac GTPase-activating protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108112.1 → NP_001101582.1 rac GTPase-activating protein 1

See identical proteins and their annotated locations for NP_001101582.1

Status: PROVISIONAL

Source sequence(s)

CH474035

UniProtKB/TrEMBL

A0A8I5ZS98, A0A9K3Y6X7, B2GV02, M0RDX1

Related

ENSRNOP00000110421.1, ENSRNOT00000123541.1

Conserved Domains (2) summary

cd00029
Location:286 → 334

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:345 → 538

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

132629789..132659738 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006257400.5 → XP_006257462.1 rac GTPase-activating protein 1 isoform X1

See identical proteins and their annotated locations for XP_006257462.1

UniProtKB/TrEMBL

A0A8I5ZS98, A0A9K3Y6X7, B2GV02, M0RDX1

Related

ENSRNOP00000067834.3, ENSRNOT00000071885.4

Conserved Domains (2) summary

cd00029
Location:286 → 334

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd04382
Location:345 → 538

RhoGAP_MgcRacGAP; RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin ...
XM_039079329.2 → XP_038935257.1 rac GTPase-activating protein 1 isoform X2

Conserved Domains (2) summary

cd04382
Location:169 → 362

RhoGAP_MgcRacGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is ...

cd20821
Location:108 → 161

C1_MgcRacGAP; protein kinase C conserved region 1 (C1 domain) found in male germ cell RacGap (MgcRacGAP) and similar proteins