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    Gpr19 G protein-coupled receptor 19 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312787, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gpr19provided by RGD
    Official Full Name
    G protein-coupled receptor 19provided by RGD
    Primary source
    RGD:71045
    See related
    EnsemblRapid:ENSRNOG00000007126 AllianceGenome:RGD:71045
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in cilium and neuron projection. Predicted to be active in plasma membrane. Orthologous to human GPR19 (G protein-coupled receptor 19). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 18.3), Brain (RPKM 15.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr19 in Genome Data Viewer
    Location:
    4q43
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (169442278..169468805, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (167710944..167739232, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (168639930..168668345, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 16 Neighboring gene cAMP responsive element binding protein-like 2 Neighboring gene uncharacterized LOC108350781 Neighboring gene cyclin-dependent kinase inhibitor 1B Neighboring gene proteasome maturation protein pseudogene Neighboring gene apolipoprotein L domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. O'Dowd BF, et al. FEBS Lett, 1996 Oct 7. PMID 8830667
    2. Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins. Badgandi HB, et al. J Cell Biol, 2017 Mar 6. PMID 28154160, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080579.2 → NP_542146.1  probable G-protein coupled receptor 19

      See identical proteins and their annotated locations for NP_542146.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P70585, Q5FVI1
      UniProtKB/TrEMBL
      A6IME4, A6IME5
      Related
      ENSRNOP00000085068.1, ENSRNOT00000116148.2
      Conserved Domains (2) summary
      pfam00001
      Location:82 → 330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72 → 258
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      169442278..169468805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107696.2 → XP_038963624.1  probable G-protein coupled receptor 19 isoform X1

      Related
      ENSRNOP00000009341.5, ENSRNOT00000009341.7
      Conserved Domains (1) summary
      cd15008
      Location:214 → 488
      7tmA_GPR19; G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_006237522.5 → XP_006237584.1  probable G-protein coupled receptor 19 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GFK1, A6IME5
      Related
      ENSRNOP00000093658.2, ENSRNOT00000095765.2
      Conserved Domains (2) summary
      pfam00001
      Location:105 → 353
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:95 → 281
      7tm_4; Olfactory receptor

    3. XM_006237524.4 → XP_006237586.1  probable G-protein coupled receptor 19 isoform X3

      See identical proteins and their annotated locations for XP_006237586.1

      UniProtKB/Swiss-Prot
      P70585, Q5FVI1
      UniProtKB/TrEMBL
      A6IME4, A6IME5
      Conserved Domains (2) summary
      pfam00001
      Location:82 → 330
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:72 → 258
      7tm_4; Olfactory receptor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70585.2 GenPept UniProtKB/Swiss-Prot:P70585

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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