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    Jazf1 JAZF zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Jazf1provided by RGD
    Official Full Name
    JAZF zinc finger 1provided by RGD
    Primary source
    RGD:1589007
    See related
    EnsemblRapid:ENSRNOG00000027026 AllianceGenome:RGD:1589007
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription corepressor activity. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human JAZF1 (JAZF zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 42.4), Thymus (RPKM 41.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Jazf1 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (83210054..83513790, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (81879501..82183237, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (82834181..83141430, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486581 Neighboring gene Tax1 binding protein 1 Neighboring gene uncharacterized LOC108350711 Neighboring gene serine and arginine rich splicing factor 7, pseudogene 5 Neighboring gene uncharacterized LOC134486580 Neighboring gene uncharacterized LOC120102280

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effect of central JAZF1 on glucose production is regulated by the PI3K-Akt-AMPK pathway. Zhou M, et al. FASEB J, 2020 May. PMID 32275331
    2. TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. Nakajima T, et al. Nucleic Acids Res, 2004. PMID 15302918, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Effect of central JAZF1 on glucose production is regulated by the PI3K-Akt-AMPK pathway.
      Title: Effect of central JAZF1 on glucose production is regulated by the PI3K-Akt-AMPK pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    juxtaposed with another zinc finger protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001400852.1 → NP_001387781.1  juxtaposed with another zinc finger protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      D3ZA80
      Related
      ENSRNOP00000036865.4, ENSRNOT00000039580.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      83210054..83513790 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108679.2 → XP_038964607.1  juxtaposed with another zinc finger protein 1 isoform X2

      UniProtKB/TrEMBL
      A6K0S9
      Conserved Domains (1) summary
      COG5189
      Location:105 → 166
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

    2. XM_063286691.1 → XP_063142761.1  juxtaposed with another zinc finger protein 1 isoform X2

      UniProtKB/TrEMBL
      A6K0S9

    3. XM_063286690.1 → XP_063142760.1  juxtaposed with another zinc finger protein 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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