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    U2surp U2 snRNP-associated SURP domain containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    U2surpprovided by RGD
    Official Full Name
    U2 snRNP-associated SURP domain containingprovided by RGD
    Primary source
    RGD:1307882
    See related
    EnsemblRapid:ENSRNOG00000008607 AllianceGenome:RGD:1307882
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307882
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA processing. Predicted to be located in nucleoplasm. Predicted to be part of U2 snRNP. Predicted to be active in nucleus. Orthologous to human U2SURP (U2 snRNP associated SURP domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 181.1), Brain (RPKM 171.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See U2surp in Genome Data Viewer
    Location:
    8q31
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (104898580..104963642, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (96018932..96075795, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (103242095..103299082, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 2 Neighboring gene Fcf1 rRNA-processing protein, pseudogene 1 Neighboring gene uncharacterized LOC120094231 Neighboring gene progestin and adipoQ receptor family member 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways. Gilmore-Hebert M, et al. Mol Cancer Res, 2010 Oct. PMID 20858735, Free PMC Article
    2. p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes. Dumont AA, et al. Biochim Biophys Acta Mol Cell Res, 2019 Dec. PMID 31505169
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2 snRNP IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    U2 snRNP-associated SURP domain containing; U2 snRNP-associated SURP motif-containing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430540.1 → NP_001417469.1  U2 snRNP-associated SURP domain containing isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZXP5

    2. NM_001430541.1 → NP_001417470.1  U2 snRNP-associated SURP domain containing isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I255

    3. NM_001430542.1 → NP_001417471.1  U2 snRNP-associated SURP domain containing isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZXP5, D4A4B4

    4. NM_001430543.1 → NP_001417472.1  U2 snRNP-associated SURP domain containing isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6I255

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      104898580..104963642 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243554.3 → XP_006243616.1  U2 snRNP-associated SURP motif-containing protein isoform X2

      Conserved Domains (4) summary
      smart00582
      Location:540 → 675
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      cd12223
      Location:272 → 355
      RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
      pfam01805
      Location:429 → 479
      Surp; Surp module
      pfam08312
      Location:842 → 883
      cwf21; cwf21 domain

    2. XM_039082560.2 → XP_038938488.1  U2 snRNP-associated SURP motif-containing protein isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZXP5
      Conserved Domains (5) summary
      smart00582
      Location:541 → 676
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      COG0724
      Location:156 → 352
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam01805
      Location:429 → 480
      Surp; Surp module
      cd12223
      Location:273 → 356
      RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
      cd21370
      Location:836 → 884
      cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

    3. XM_039082559.2 → XP_038938487.1  U2 snRNP-associated SURP motif-containing protein isoform X4

      Conserved Domains (5) summary
      smart00582
      Location:496 → 631
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      COG0724
      Location:112 → 307
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam01805
      Location:384 → 435
      Surp; Surp module
      cd12223
      Location:228 → 311
      RRM_SR140; RNA recognition motif (RRM) found in U2-associated protein SR140 and similar proteins
      cd21370
      Location:791 → 839
      cwf21_SR140; cwf21 domain found in U2-associated protein SR140 and similar proteins

    4. XM_002729954.7 → XP_002730000.1  U2 snRNP-associated SURP motif-containing protein isoform X3

      Related
      ENSRNOP00000011609.6, ENSRNOT00000011609.9
      Conserved Domains (4) summary
      smart00582
      Location:497 → 632
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      cd12223
      Location:229 → 312
      RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
      pfam01805
      Location:386 → 436
      Surp; Surp module
      pfam08312
      Location:799 → 840
      cwf21; cwf21 domain

    5. XM_236501.10 → XP_236501.3  U2 snRNP-associated SURP motif-containing protein isoform X1

      Related
      ENSRNOP00000083935.1, ENSRNOT00000116411.2
      Conserved Domains (4) summary
      smart00582
      Location:541 → 676
      RPR; domain present in proteins, which are involved in regulation of nuclear pre-mRNA
      cd12223
      Location:273 → 356
      RRM_SR140; RNA recognition motif (RRM) in U2-associated protein SR140 and similar proteins
      pfam01805
      Location:430 → 480
      Surp; Surp module
      pfam08312
      Location:843 → 884
      cwf21; cwf21 domain

    6. XM_017596120.3 → XP_017451609.1  U2 snRNP-associated SURP motif-containing protein isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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