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    Mcat malonyl-CoA-acyl carrier protein transacylase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315173, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mcatprovided by RGD
    Official Full Name
    malonyl-CoA-acyl carrier protein transacylaseprovided by RGD
    Primary source
    RGD:1306698
    See related
    EnsemblRapid:ENSRNOG00000010539 AllianceGenome:RGD:1306698
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306698
    Summary
    Predicted to enable [acyl-carrier-protein] S-malonyltransferase activity. Predicted to be involved in fatty acid biosynthetic process and mitochondrial small ribosomal subunit assembly. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in optic atrophy. Orthologous to human MCAT (malonyl-CoA-acyl carrier protein transacylase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 169.0), Adrenal (RPKM 92.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mcat in Genome Data Viewer
    Location:
    7q34
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (116573632..116585767, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (114693612..114705677, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (124412762..124424966, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene TTL family tubulin polyglutamylase complex subunit L1 Neighboring gene BCL2-interacting killer Neighboring gene uncharacterized LOC134479952 Neighboring gene uncharacterized LOC134479950 Neighboring gene translocator protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning, expression, characterization, and interaction of two components of a human mitochondrial fatty acid synthase. Malonyltransferase and acyl carrier protein. Zhang L, et al. J Biol Chem, 2003 Oct 10. PMID 12882974
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables [acyl-carrier-protein] S-malonyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [acyl-carrier-protein] S-malonyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial small ribosomal subunit assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    malonyl-CoA-acyl carrier protein transacylase, mitochondrial
    Names
    malonyl CoA:ACP acyltransferase (mitochondrial)
    NP_001178717.1
    XP_006242153.1
    XP_063119692.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191788.1 → NP_001178717.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial

      See identical proteins and their annotated locations for NP_001178717.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D3ZPF2
      Related
      ENSRNOP00000013994.5, ENSRNOT00000013994.7
      Conserved Domains (1) summary
      cl08282
      Location:63 → 356
      Acyl_transf_1; Acyl transferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      116573632..116585767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006242091.2 → XP_006242153.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006242153.1

      UniProtKB/TrEMBL
      D3ZPF2
      Conserved Domains (1) summary
      cl08282
      Location:63 → 356
      Acyl_transf_1; Acyl transferase domain

    2. XM_063263622.1 → XP_063119692.1  malonyl-CoA-acyl carrier protein transacylase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A6HT99
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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