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    Tmem63b transmembrane protein 63B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem63bprovided by RGD
    Official Full Name
    transmembrane protein 63Bprovided by RGD
    Primary source
    RGD:1305862
    See related
    EnsemblRapid:ENSRNOG00000019743 AllianceGenome:RGD:1305862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305862; Tmem63b-ps1
    Summary
    Predicted to enable calcium-activated cation channel activity; mechanosensitive monoatomic cation channel activity; and osmolarity-sensing monoatomic cation channel activity. Predicted to be involved in sensory perception of sound. Predicted to be located in actin cytoskeleton; alveolar lamellar body membrane; and early endosome membrane. Predicted to be active in plasma membrane. Orthologous to human TMEM63B (transmembrane protein 63B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 183.7), Adrenal (RPKM 143.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmem63b in Genome Data Viewer
    Location:
    9q12
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22810753..22838163)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (15313867..15340722)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17698697..17725479)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550363 Neighboring gene uncharacterized LOC103690501 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene calpain 11 Neighboring gene myomixer, myoblast fusion factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Overexpression of Osmosensitive Ca(2+)-Permeable Channel TMEM63B Promotes Migration in HEK293T Cells. Marques MC, et al. Biochemistry, 2019 Jul 2. PMID 31243992
    2. Co-expression of mouse TMEM63A, TMEM63B and TMEM63C confers hyperosmolarity activated ion currents in HEK293 cells. Zhao X, et al. Cell Biochem Funct, 2016 Jun. PMID 27045885
    3. OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels. Murthy SE, et al. Elife, 2018 Nov 1. PMID 30382938, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mechanosensitive monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mechanosensitive monoatomic ion channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables osmolarity-sensing monoatomic cation channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in surfactant secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in surfactant secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in alveolar lamellar body membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    CSC1-like protein 2
    Names
    transmembrane protein 63B, pseudogene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427713.1 → NP_001414642.1  CSC1-like protein 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A8I6GGL9, D4A105

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      22810753..22838163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267361.1 → XP_063123431.1  CSC1-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GGL9, D4A105

    2. XM_006244582.4 → XP_006244644.1  CSC1-like protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006244644.1

      UniProtKB/TrEMBL
      A0A8I5ZKC7, A0A8I6GGL9
      Related
      ENSRNOP00000077670.1, ENSRNOT00000096202.2
      Conserved Domains (3) summary
      pfam02714
      Location:420 → 691
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:52 → 208
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:227 → 409
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    3. XM_039084826.2 → XP_038940754.1  CSC1-like protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZKC7, A0A8I6GGL9
      Conserved Domains (3) summary
      pfam02714
      Location:420 → 691
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:52 → 208
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:227 → 409
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter

    4. XM_039084824.2 → XP_038940752.1  CSC1-like protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GGL9, D4A105
      Related
      ENSRNOP00000026728.3, ENSRNOT00000026728.6
      Conserved Domains (3) summary
      pfam02714
      Location:433 → 704
      RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
      pfam13967
      Location:52 → 221
      RSN1_TM; Late exocytosis, associated with Golgi transport
      pfam14703
      Location:240 → 422
      PHM7_cyt; Cytosolic domain of 10TM putative phosphate transporter
    Nucleotide Protein Strain
    Heading Accession and Version

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