Sord sorbitol dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sordprovided by RGD
Official Full Name: sorbitol dehydrogenaseprovided by RGD
Primary source: RGD:3734
See related: EnsemblRapid:ENSRNOG00000017291 AllianceGenome:RGD:3734
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SDH; XDH
Summary: Enables identical protein binding activity and zinc ion binding activity. Involved in several processes, including response to cadmium ion; response to copper ion; and response to hormone. Predicted to be located in several cellular components, including extracellular exosome; mitochondrion; and motile cilium. Predicted to be active in cytosol. Used to study diabetic neuropathy. Human ortholog(s) of this gene implicated in autosomal recessive distal hereditary motor neuronopathy 8. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 2300.8), Kidney (RPKM 1771.3) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (129638282..129669727)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (109184697..109216133)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (114176127..114207368)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SORD-deficient rats develop a motor-predominant peripheral neuropathy unveiling novel pathophysiological insights.
Title: SORD-deficient rats develop a motor-predominant peripheral neuropathy unveiling novel pathophysiological insights.
Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method.
Title: Gene expression of enzymes comprising the polyol pathway in various rat tissues determined by the competitive RT-PCR method.
Sorbitol dehydrogenase is expressed almost ubiquitously in all mammalian tissues.
Title: Sorbitol dehydrogenase: structure, function and ligand design.

Submit: New GeneRIF Correction

General gene information

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Markers

RH130513 (e-PCR)
- UniSTS:213797

NoName (e-PCR)
- UniSTS:547147

Sord (e-PCR), detects polymorphism
- UniSTS:547147

PMC86057P1 (e-PCR)
- UniSTS:273513

RH141218 (e-PCR)
- UniSTS:223214

G36383 (e-PCR)
- UniSTS:44529

BF387718 (e-PCR)
- UniSTS:261107

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-sorbitol dehydrogenase (acceptor) activity	IEA Inferred from Electronic Annotation more info
enables D-sorbitol dehydrogenase (acceptor) activity	ISO Inferred from Sequence Orthology more info
enables D-xylulose reductase activity	IEA Inferred from Electronic Annotation more info
enables D-xylulose reductase activity	ISO Inferred from Sequence Orthology more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables L-iditol 2-dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate	IEA Inferred from Electronic Annotation more info
involved_in D-glucuronate catabolic process to D-xylulose 5-phosphate	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	IEA Inferred from Electronic Annotation more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in fructose biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fructose biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in response to cadmium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sorbitol catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sorbitol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in sorbitol catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sorbitol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xylitol catabolic process	IEA Inferred from Electronic Annotation more info
involved_in xylitol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xylitol metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in motile cilium	IEA Inferred from Electronic Annotation more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
located_in motile cilium	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: sorbitol dehydrogenase

Names: L-iditol 2-dehydrogenase; polyol dehydrogenase; xylitol dehydrogenase

NP_058748.2

EC 1.1.1.14

EC 1.1.1.9

XP_017446963.1

EC 1.1.1.14

EC 1.1.1.9

XP_063139178.1

EC 1.1.1.14

EC 1.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.