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    Fgf11 fibroblast growth factor 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170632, updated on 9-Dec-2024

    Summary

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    Symbol
    Fgf11provided by RGD
    Full Name
    fibroblast growth factor 11provided by RGD
    Primary source
    RGD:620162
    See related
    AllianceGenome:RGD:620162
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fgf1d
    Summary
    Predicted to enable sodium channel regulator activity. Predicted to be involved in neurogenesis and regulation of voltage-gated sodium channel activity. Predicted to be active in cytoplasm and nucleus. Orthologous to human FGF11 (fibroblast growth factor 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 33.4), Spleen (RPKM 14.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fgf11 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55015232..55020773, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54516508..54522067, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56403320..56410816, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member G3 Neighboring gene zinc finger and BTB domain containing 4 Neighboring gene cholinergic receptor nicotinic beta 1 subunit Neighboring gene transmembrane protein 102 Neighboring gene SPEM family member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs. Olsen SK, et al. J Biol Chem, 2003 Sep 5. PMID 12815063
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sodium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in neurogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of voltage-gated sodium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fibroblast growth factor 11
    Names
    fibroblast growth factor 1d

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130816.1 → NP_570829.1  fibroblast growth factor 11

      See identical proteins and their annotated locations for NP_570829.1

      Status: PROVISIONAL

      Source sequence(s)
      AB079263
      UniProtKB/TrEMBL
      Q8R5L8
      Conserved Domains (1) summary
      smart00442
      Location:69 → 199
      FGF; Acidic and basic fibroblast growth factor family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55015232..55020773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017596975.3 → XP_017452464.1  fibroblast growth factor 11 isoform X1

      Conserved Domains (1) summary
      smart00442
      Location:69 → 199
      FGF; Acidic and basic fibroblast growth factor family

    2. XM_039085115.2 → XP_038941043.1  fibroblast growth factor 11 isoform X2

      Conserved Domains (1) summary
      cl00060
      Location:69 → 171
      FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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