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    Eif4h eukaryotic translation initiation factor 4H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288599, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Eif4hprovided by RGD
    Official Full Name
    eukaryotic translation initiation factor 4Hprovided by RGD
    Primary source
    RGD:1359222
    See related
    EnsemblRapid:ENSRNOG00000001454 AllianceGenome:RGD:1359222
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wbscr1
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in translational initiation. Predicted to act upstream of or within developmental growth and sexual reproduction. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human EIF4H (eukaryotic translation initiation factor 4H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 551.8), Kidney (RPKM 531.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif4h in Genome Data Viewer
    Location:
    12q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27719527..27736350)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22083155..22099876)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25093119..25109805)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene LIM domain kinase 1 Neighboring gene 40S ribosomal protein S14 pseudogene Neighboring gene linker for activation of T cells family, member 2 Neighboring gene replication factor C subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Growth defects and impaired cognitive-behavioral abilities in mice with knockout for Eif4h, a gene located in the mouse homolog of the Williams-Beuren syndrome critical region. Capossela S, et al. Am J Pathol, 2012 Mar. PMID 22234171
    2. Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. Richter-Cook NJ, et al. J Biol Chem, 1998 Mar 27. PMID 9516461
    3. mRNA helicases: the tacticians of translational control. Parsyan A, et al. Nat Rev Mol Cell Biol, 2011 Apr. PMID 21427765
    4. Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. Osborne LR, et al. Genomics, 1996 Sep 1. PMID 8812460
    5. Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. Martindale DW, et al. Mamm Genome, 2000 Oct. PMID 11003705

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94887

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA strand annealing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA strand-exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosomal small subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within developmental growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in eukaryotic translation initiation factor 4F complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sexual reproduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 4H
    Names
    Williams-Beuren syndrome chromosome region 1 homolog
    eIF-4H
    williams-Beuren syndrome chromosomal region 1 protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006957.2 → NP_001006958.1  eukaryotic translation initiation factor 4H

      See identical proteins and their annotated locations for NP_001006958.1

      Status: VALIDATED

      Source sequence(s)
      BC083818, CB718613
      UniProtKB/Swiss-Prot
      Q5XI72
      UniProtKB/TrEMBL
      A0A8L2QL20
      Related
      ENSRNOP00000043254.4, ENSRNOT00000050059.6
      Conserved Domains (2) summary
      TIGR01622
      Location:40 → 227
      SF-CC1; splicing factor, CC1-like family
      cd12401
      Location:37 → 120
      RRM_eIF4H; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      27719527..27736350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249134.4 → XP_006249196.2  eukaryotic translation initiation factor 4H isoform X1

      UniProtKB/TrEMBL
      A0A8L2QL20
      Conserved Domains (2) summary
      TIGR01622
      Location:40 → 207
      SF-CC1; splicing factor, CC1-like family
      cd12401
      Location:37 → 120
      RRM_eIF4H; RNA recognition motif (RRM) found in eukaryotic translation initiation factor 4H (eIF-4H) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XI72.1 GenPept UniProtKB/Swiss-Prot:Q5XI72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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