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    SLC35D3 solute carrier family 35 member D3 [ Homo sapiens (human) ]

    Gene ID: 340146, updated on 27-Nov-2024

    Summary

    Official Symbol
    SLC35D3provided by HGNC
    Official Full Name
    solute carrier family 35 member D3provided by HGNC
    Primary source
    HGNC:HGNC:15621
    See related
    Ensembl:ENSG00000182747 MIM:612519; AllianceGenome:HGNC:15621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRCL1
    Summary
    Enables UDP-glucose transmembrane transporter activity. Involved in UDP-glucose transmembrane transport. Is active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC35D3 in Genome Data Viewer
    Location:
    6q23.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (136922301..136925660)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (138110480..138113839)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (137243439..137246798)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene small nucleolar RNA SNORA27 Neighboring gene ribosomal protein L7a pseudogene 37 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:137242461-137242967 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137277696-137278264 Neighboring gene Sharpr-MPRA regulatory region 8118 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137279401-137279967 Neighboring gene NANOG hESC enhancer GRCh37_chr6:137298202-137298732 Neighboring gene ribosomal protein L35a pseudogene 3 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:137311375-137312331 Neighboring gene neuroblastoma highly expressed DDX5 stabilizing lncRNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102873

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables UDP-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in UDP-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in energy homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in platelet dense granule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein exit from endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein exit from endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    solute carrier family 35 member D3
    Names
    frc, fringe-like 1
    fringe connection-like protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008783.3NP_001008783.1  solute carrier family 35 member D3

      See identical proteins and their annotated locations for NP_001008783.1

      Status: VALIDATED

      Source sequence(s)
      AK295424, AK316095, BC067217, BE669463
      Consensus CDS
      CCDS34544.1
      UniProtKB/Swiss-Prot
      B4DI58, Q5M8T2, Q5QNZ6, Q6NX71
      UniProtKB/TrEMBL
      B7Z9Y0
      Related
      ENSP00000333591.4, ENST00000331858.5
      Conserved Domains (1) summary
      COG5070
      Location:30308
      VRG4; Nucleotide-sugar transporter [Carbohydrate transport and metabolism / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      136922301..136925660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      138110480..138113839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)