U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GTF3C6 general transcription factor IIIC subunit 6 [ Homo sapiens (human) ]

    Gene ID: 112495, updated on 9-Dec-2024

    Summary

    Official Symbol
    GTF3C6provided by HGNC
    Official Full Name
    general transcription factor IIIC subunit 6provided by HGNC
    Primary source
    HGNC:HGNC:20872
    See related
    Ensembl:ENSG00000155115 MIM:611784; AllianceGenome:HGNC:20872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    C6orf51; TFIIIC35; bA397G5.3
    Summary
    RNA polymerases are unable to initiate RNA synthesis in the absence of additional proteins called general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins (e.g., GTF3C1, MIM 603246) are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA (MIM 180420), tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin.[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in prostate (RPKM 34.5), testis (RPKM 28.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GTF3C6 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (110958706..110967872)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (112137328..112146494)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (111279909..111289075)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene adenosylmethionine decarboxylase 1 Neighboring gene Sharpr-MPRA regulatory region 678 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111196410-111197125 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:111197126-111197840 Neighboring gene RBIS pseudogene 4 Neighboring gene PDGFA associated protein 1 pseudogene Neighboring gene MPRA-validated peak6032 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24939 Neighboring gene Sharpr-MPRA regulatory region 5639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24940 Neighboring gene small nucleolar RNA U13 Neighboring gene ribosome production factor 2 homolog Neighboring gene uncharacterized LOC124901375 Neighboring gene RNA, U6 small nuclear 906, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    general transcription factor 3C polypeptide 6
    Names
    TFIIIC 35 kDa subunit
    general transcription factor IIIC, polypeptide 6, alpha 35kDa
    transcription factor IIIC 35 kDa subunit
    transcription factor IIIC 35kDa
    transcription factor IIIC subunit 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138408.4NP_612417.1  general transcription factor 3C polypeptide 6

      See identical proteins and their annotated locations for NP_612417.1

      Status: VALIDATED

      Source sequence(s)
      AF361496
      Consensus CDS
      CCDS5087.1
      UniProtKB/Swiss-Prot
      Q5VXN2, Q969F1
      Related
      ENSP00000357863.4, ENST00000329970.8
      Conserved Domains (1) summary
      pfam10419
      Location:4376
      TFIIIC_sub6; TFIIIC subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      110958706..110967872
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      112137328..112146494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)