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    BNIP3 BCL2 interacting protein 3 [ Homo sapiens (human) ]

    Gene ID: 664, updated on 4-Jan-2025

    Summary

    Official Symbol
    BNIP3provided by HGNC
    Official Full Name
    BCL2 interacting protein 3provided by HGNC
    Primary source
    HGNC:HGNC:1084
    See related
    Ensembl:ENSG00000176171 MIM:603293; AllianceGenome:HGNC:1084
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NIP3; HABON
    Summary
    This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in liver (RPKM 54.5), fat (RPKM 52.6) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BNIP3 in Genome Data Viewer
    Location:
    10q26.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (131967684..131981923, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (132907935..132922186, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (133781188..133795427, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378566 Neighboring gene 60S ribosomal protein L19-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4220 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2947 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2948 Neighboring gene Sharpr-MPRA regulatory region 4393 Neighboring gene protein phosphatase 2 regulatory subunit Bdelta Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:133747865-133749064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133758459-133759288 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133761987-133762488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133785771-133786641 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133794606-133795530 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2952 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133809534-133810520 Neighboring gene uncharacterized LOC124902525 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133820384-133820908 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:133823019-133823543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133832958-133833629 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133842692-133843192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133852590-133853427 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133857569-133858086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133858087-133858604 Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133878227-133878974 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:133881249-133881749 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11218 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11222 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11225 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_11227 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133920928-133921428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133933330-133934168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133934169-133935006 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133951279-133951800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133955152-133955999 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133956000-133956846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959409-133959910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133959911-133960410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:133960832-133961794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:133977007-133977706 Neighboring gene JAKMIP3 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of BCL2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) in human B cells PubMed
    Vpr vpr Treatment of human primary astrocytes with HIV-1 Vpr downregulates expression of eleven genes, BNIP3, CYGB, DUOX2, DUSP1, FOXM1, GAPDH, HPRT1, MT3, MTL5, PTGS2, and SCARA3 PubMed
    vpr Overexpression of BNIP3 is induced by HIV-1 Vpr in the transfected 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Items 1 - 25 of 47
    Process Evidence Code Pubs
    involved_in autophagic cell death  
    involved_in autophagy of mitochondrion PubMed 
    involved_in brown fat cell differentiation  
    involved_in cardiac muscle cell apoptotic process  
    involved_in cellular response to cobalt ion PubMed 
    involved_in cellular response to hydrogen peroxide  
    acts_upstream_of_or_within cellular response to hypoxia PubMed 
    involved_in cellular response to hypoxia PubMed 
    involved_in cellular response to mechanical stimulus  
    involved_in cerebral cortex development  
    involved_in defense response to virus PubMed 
    involved_in granzyme-mediated programmed cell death signaling pathway PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to hypoxia PubMed 
    involved_in mitochondrial fragmentation involved in apoptotic process PubMed 
    involved_in mitochondrial outer membrane permeabilization  
    involved_in mitochondrial outer membrane permeabilization PubMed 
    involved_in mitochondrial protein catabolic process PubMed 
    involved_in mitophagy PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of membrane potential PubMed 
    involved_in negative regulation of mitochondrial fusion PubMed 
    involved_in negative regulation of mitochondrial membrane permeability involved in apoptotic process  
    involved_in negative regulation of mitochondrial membrane potential  
    acts_upstream_of_or_within negative regulation of programmed cell death PubMed 
    involved_in negative regulation of reactive oxygen species metabolic process  
    involved_in neuron apoptotic process  
    involved_in oligodendrocyte differentiation  
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of autophagy PubMed 
    involved_in positive regulation of autophagy of mitochondrion  
    involved_in positive regulation of cardiac muscle cell apoptotic process  
    acts_upstream_of_or_within positive regulation of macroautophagy PubMed 
    involved_in positive regulation of mitochondrial calcium ion concentration  
    involved_in positive regulation of mitochondrial fission PubMed 
    involved_in positive regulation of programmed cell death  
    involved_in positive regulation of programmed cell death PubMed 
    involved_in positive regulation of protein-containing complex disassembly PubMed 
    involved_in positive regulation of release of cytochrome c from mitochondria PubMed 
    involved_in reactive oxygen species metabolic process PubMed 
    involved_in regulation of aerobic respiration  
    involved_in regulation of mitochondrial membrane permeability PubMed 
    involved_in response to axon injury  
    involved_in response to bacterium  
    involved_in response to hyperoxia  
    involved_in response to hypoxia  
    involved_in response to oxygen-glucose deprivation  
    involved_in reticulophagy PubMed 
    Items 1 - 25 of 47
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in dendrite  
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    is_active_in endoplasmic reticulum membrane PubMed 
    located_in mitochondrial membrane PubMed 
    located_in mitochondrial membrane PubMed 
    is_active_in mitochondrial outer membrane  
    is_active_in mitochondrial outer membrane PubMed 
    located_in mitochondrial outer membrane PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    located_in mitochondrion PubMed 
    is_active_in nuclear envelope  
    located_in nuclear envelope PubMed 
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in postsynaptic density  

    General protein information

    Preferred Names
    BCL2/adenovirus E1B 19 kDa protein-interacting protein 3
    Names
    BCL2/adenovirus E1B 19kDa interacting protein 3
    BCL2/adenovirus E1B interacting protein 3
    Hypoxia-Activated BNIP3 Overlapping Non-coding RNA
    nineteen kD interacting protein-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004052.4 → NP_004043.4  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

      Status: REVIEWED

      Source sequence(s)
      AL162274, AL732395
      Consensus CDS
      CCDS7663.3
      UniProtKB/Swiss-Prot
      O14620, Q12983, Q96GP0
      UniProtKB/TrEMBL
      Q53HF4
      Related
      ENSP00000357625.6, ENST00000368636.9
      Conserved Domains (1) summary
      pfam06553
      Location:9 → 192
      BNIP3

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      131967684..131981923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      132907935..132922186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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