FGB fibrinogen beta chain [Homo sapiens (human)] - Gene

Summary

Official Symbol: FGBprovided by HGNC
Official Full Name: fibrinogen beta chainprovided by HGNC
Primary source: HGNC:HGNC:3662
See related: Ensembl:ENSG00000171564 MIM:134830; AllianceGenome:HGNC:3662
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HEL-S-78p
Summary: The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Fibrinogen serves key roles in hemostasis and antimicrobial host defense. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Aug 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is relevant for disease process.
Expression: Restricted expression toward liver (RPKM 2456.5) See more
Orthologs: mouse all
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Genomic context

Location:: 4q31.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (154562980..154572807)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (157894764..157904590)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (155484132..155493959)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Novel Fibrinogen Mutation p.BbetaAla68Asp Causes an Inherited Dysfibrinogenemia.
Title: A Novel Fibrinogen Mutation p.BβAla68Asp Causes an Inherited Dysfibrinogenemia.
[Genetic analysis of a Chinese pedigree affected with Congenital dysfibrinogenemia due to variant of FGG gene].
Title: [Genetic analysis of a Chinese pedigree affected with Congenital dysfibrinogenemia due to variant of FGG gene].
Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears.
Title: Pathogenic Role of Fibrinogen in the Neuropathology of Multiple Sclerosis: A Tale of Sorrows and Fears.
Association between lipoprotein(a) and ischemic stroke: Fibrinogen as a mediator.
Title: Association between lipoprotein(a) and ischemic stroke: Fibrinogen as a mediator.
The role of fibrinogen in traumatic brain injury: from molecular pathological mechanisms to clinical management.
Title: The role of fibrinogen in traumatic brain injury: from molecular pathological mechanisms to clinical management.
Impact of Fibrinogen, Fibrin Thrombi, and Thrombin on Cancer Cell Extravasation Using In Vitro Microvascular Networks.
Title: Impact of Fibrinogen, Fibrin Thrombi, and Thrombin on Cancer Cell Extravasation Using In Vitro Microvascular Networks.
Association between fibrinogen level and length of stay in patients with lower extremity atherosclerotic disease: a retrospective cohort study.
Title: Association between fibrinogen level and length of stay in patients with lower extremity atherosclerotic disease: a retrospective cohort study.
Glycoprotein VI interplay with fibrin(ogen) in thrombosis.
Title: Glycoprotein VI interplay with fibrin(ogen) in thrombosis.
Evaluating the Association Between Fibrinogen and Rotational Thromboelastometry and the Progression to Severe Obstetric Hemorrhage.
Title: Evaluating the Association Between Fibrinogen and Rotational Thromboelastometry and the Progression to Severe Obstetric Hemorrhage.
Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients.
Title: Interaction Between Platelet and Fibrinogen on Clot Strength in Healthy Patients.

Submit: New GeneRIF Correction See all GeneRIFs (222)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital afibrinogenemia MedGen: C2584774 OMIM: 202400 GeneReviews: Not available	not available
Familial dysfibrinogenemia MedGen: C0272350 OMIM: 616004 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Assessment of genetic determinants of the association of &#x003b3;' fibrinogen in relation to cardiovascular disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:374037 (e-PCR)
- UniSTS:156935

GDB:374038 (e-PCR)
- UniSTS:156936

SHGC-67362 (e-PCR)
- UniSTS:50955

GDB:633014 (e-PCR)
- UniSTS:158507

G54120 (e-PCR)
- UniSTS:109357

RH11045 (e-PCR)
- UniSTS:40262

G20311 (e-PCR)
- UniSTS:20306

A005L26 (e-PCR)
- UniSTS:20307

NoName (e-PCR)
- UniSTS:487001

SHGC-59513 (e-PCR)
- UniSTS:27740

D4S2883 (e-PCR)
- UniSTS:72811

G33709 (e-PCR)
- UniSTS:45937

SHGC-33093 (e-PCR)
- UniSTS:21362

SHGC-59327 (e-PCR)
- UniSTS:81533

RH36633 (e-PCR)
- UniSTS:67013

G44712 (e-PCR)
- UniSTS:95187

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
contributes_to cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix structural constituent	HDA more info	PubMed
enables extracellular matrix structural constituent	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables structural molecule activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation, fibrin clot formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in blood coagulation, fibrin clot formation	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
involved_in cellular response to leptin stimulus	IEA Inferred from Electronic Annotation more info
involved_in fibrinolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in induction of bacterial agglutination	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
involved_in plasminogen activation	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet aggregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of heterotypic cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptide hormone secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of vasoconstriction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in blood microparticle	HDA more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular vesicle	HDA more info	PubMed
part_of fibrinogen complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in platelet alpha granule	IDA Inferred from Direct Assay more info	PubMed
located_in platelet alpha granule lumen	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibrinogen beta chain

Names: beta-fibrinogen; epididymis secretory sperm binding protein Li 78p; fibrinogen, B beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008833.1 RefSeqGene

Range

5001..14784

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_558

mRNA and Protein(s)

NM_001184741.1 → NP_001171670.1 fibrinogen beta chain isoform 2 preproprotein

See identical proteins and their annotated locations for NP_001171670.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC107385, AK312972, BC036007

UniProtKB/TrEMBL

B4E1D3

Conserved Domains (2) summary

pfam08702
Location:57 → 175

Fib_alpha; Fibrinogen alpha/beta chain family

cl00085
Location:178 → 427

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001382759.1 → NP_001369688.1 fibrinogen beta chain isoform 3 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

UniProtKB/TrEMBL

B4E1D3

Conserved Domains (2) summary

pfam00147
Location:193 → 442

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam08702
Location:96 → 190

Fib_alpha; Fibrinogen alpha/beta chain family
NM_001382760.1 → NP_001369689.1 fibrinogen beta chain isoform 4 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

UniProtKB/TrEMBL

B4E1D3

Conserved Domains (2) summary

cd00087
Location:238 → 417

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:92 → 234

Fib_alpha; Fibrinogen alpha/beta chain family
NM_001382761.1 → NP_001369690.1 fibrinogen beta chain isoform 5 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

UniProtKB/TrEMBL

B4E1D3

Conserved Domains (2) summary

cd00087
Location:238 → 414

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:92 → 234

Fib_alpha; Fibrinogen alpha/beta chain family
NM_001382762.1 → NP_001369691.1 fibrinogen beta chain isoform 6 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

Conserved Domains (2) summary

pfam08702
Location:92 → 234

Fib_alpha; Fibrinogen alpha/beta chain family

cl00085
Location:249 → 386

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001382763.1 → NP_001369692.1 fibrinogen beta chain isoform 7 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

UniProtKB/TrEMBL

B4E1D3

Conserved Domains (1) summary

cd00087
Location:238 → 484

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001382764.1 → NP_001369693.1 fibrinogen beta chain isoform 8 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

Conserved Domains (2) summary

pfam08702
Location:92 → 234

Fib_alpha; Fibrinogen alpha/beta chain family

cl00085
Location:238 → 359

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
NM_001382765.1 → NP_001369694.1 fibrinogen beta chain isoform 9 preproprotein

Status: REVIEWED

Source sequence(s)

AC107385

UniProtKB/TrEMBL

B4E1D3

Conserved Domains (2) summary

pfam00147
Location:237 → 478

Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain

pfam08702
Location:92 → 234

Fib_alpha; Fibrinogen alpha/beta chain family
NM_005141.5 → NP_005132.2 fibrinogen beta chain isoform 1 preproprotein

See identical proteins and their annotated locations for NP_005132.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC107385, AK312972, J00129

Consensus CDS

CCDS3786.1

UniProtKB/Swiss-Prot

A0JLR9, B2R7G3, P02675, Q32Q65, Q3KPF2

UniProtKB/TrEMBL

B4E1D3, V9HVY1

Related

ENSP00000306099.4, ENST00000302068.9

Conserved Domains (2) summary

cl00085
Location:237 → 486

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam08702
Location:92 → 234

Fib_alpha; Fibrinogen alpha/beta chain family