PLEC plectin [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLECprovided by HGNC
Official Full Name: plectinprovided by HGNC
Primary source: HGNC:HGNC:9069
See related: Ensembl:ENSG00000178209 MIM:601282; AllianceGenome:HGNC:9069
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HD1; PCN; EBS1; EBSO; PLTN; EBS5A; EBS5B; EBS5C; EBS5D; EBSMD; EBSND; EBSOG; EBSPA; PLEC1; LGMD2Q; PLEC1b; LGMDR17
Summary: Plectin is a prominent member of an important family of structurally and in part functionally related proteins, termed plakins or cytolinkers, that are capable of interlinking different elements of the cytoskeleton. Plakins, with their multi-domain structure and enormous size, not only play crucial roles in maintaining cell and tissue integrity and orchestrating dynamic changes in cytoarchitecture and cell shape, but also serve as scaffolding platforms for the assembly, positioning, and regulation of signaling complexes (reviewed in PMID: 9701547, 11854008, and 17499243). Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal protein 1" or "plectin 1, intermediate filament binding 500kDa". These names were superseded by plectin. The plectin gene locus in mouse on chromosome 15 has been analyzed in detail (PMID: 10556294, 14559777), revealing a genomic exon-intron organization with well over 40 exons spanning over 62 kb and an unusual 5' transcript complexity of plectin isoforms. Eleven exons (1-1j) have been identified that alternatively splice directly into a common exon 2 which is the first exon to encode plectin's highly conserved actin binding domain (ABD). Three additional exons (-1, 0a, and 0) splice into an alternative first coding exon (1c), and two additional exons (2alpha and 3alpha) are optionally spliced within the exons encoding the acting binding domain (exons 2-8). Analysis of the human locus has identified eight of the eleven alternative 5' exons found in mouse and rat (PMID: 14672974); exons 1i, 1j and 1h have not been confirmed in human. Furthermore, isoforms lacking the central rod domain encoded by exon 31 have been detected in mouse (PMID:10556294), rat (PMID: 9177781), and human (PMID: 11441066, 10780662, 20052759). The short alternative amino-terminal sequences encoded by the different first exons direct the targeting of the various isoforms to distinct subcellular locations (PMID: 14559777). As the expression of specific plectin isoforms was found to be dependent on cell type (tissue) and stage of development (PMID: 10556294, 12542521, 17389230) it appears that each cell type (tissue) contains a unique set (proportion and composition) of plectin isoforms, as if custom-made for specific requirements of the particular cells. Concordantly, individual isoforms were found to carry out distinct and specific functions (PMID: 14559777, 12542521, 18541706). In 1996, a number of groups reported that patients suffering from epidermolysis bullosa simplex with muscular dystrophy (EBS-MD) lacked plectin expression in skin and muscle tissues due to defects in the plectin gene (PMID: 8698233, 8941634, 8636409, 8894687, 8696340). Two other subtypes of plectin-related EBS have been described: EBS-pyloric atresia (PA) and EBS-Ogna. For reviews of plectin-related diseases see PMID: 15810881, 19945614. Mutations in the plectin gene related to human diseases should be named based on the position in NM_000445 (variant 1, isoform 1c), unless the mutation is located within one of the other alternative first exons, in which case the position in the respective Reference Sequence should be used. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in skin (RPKM 18.0), colon (RPKM 16.2) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q24.3

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (143915153..143976745, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (145073432..145135033, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (144989321..145050913, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Plectin Promotes the Migration of Hepatocellular Carcinoma Cells Through Inducing F-actin Polymerization].
Title: [Plectin Promotes the Migration of Hepatocellular Carcinoma Cells Through Inducing F-actin Polymerization].
Plectin Deficiency in Fibroblasts Deranges Intermediate Filament and Organelle Morphology, Migration, and Adhesion.
Title: Plectin Deficiency in Fibroblasts Deranges Intermediate Filament and Organelle Morphology, Migration, and Adhesion.
Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation.
Title: Desmin and Plectin Recruitment to the Nucleus and Nuclei Orientation Are Lost in Emery-Dreifuss Muscular Dystrophy Myoblasts Subjected to Mechanical Stimulation.
Anterior blepharitis is associated with elevated plectin levels consistent with a pronounced intracellular response.
Title: Anterior blepharitis is associated with elevated plectin levels consistent with a pronounced intracellular response.
Role of plectin and its interacting molecules in cancer.
Title: Role of plectin and its interacting molecules in cancer.
Novel biallelic variants in the PLEC gene are associated with severe hearing loss.
Title: Novel biallelic variants in the PLEC gene are associated with severe hearing loss.
The Versatility of Plectin in Cancer: A Pan-Cancer Analysis on Potential Diagnostic and Prognostic Impacts of Plectin Isoforms.
Title: The Versatility of Plectin in Cancer: A Pan-Cancer Analysis on Potential Diagnostic and Prognostic Impacts of Plectin Isoforms.
Z-Disk-Associated Plectin (Isoform 1d): Spatial Arrangement, Interaction Partners, and Role in Filamin C Homeostasis.
Title: Z-Disk-Associated Plectin (Isoform 1d): Spatial Arrangement, Interaction Partners, and Role in Filamin C Homeostasis.
Plectin Downregulation Inhibits Migration and Suppresses Epithelial Mesenchymal Transformation of Hepatocellular Carcinoma Cells via ERK1/2 Signaling.
Title: Plectin Downregulation Inhibits Migration and Suppresses Epithelial Mesenchymal Transformation of Hepatocellular Carcinoma Cells via ERK1/2 Signaling.
Mutation update: The spectra of PLEC sequence variants and related plectinopathies.
Title: Mutation update: The spectra of PLEC sequence variants and related plectinopathies.

Submit: New GeneRIF Correction See all GeneRIFs (69)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal recessive limb-girdle muscular dystrophy type 2Q MedGen: C3150989 OMIM: 613723 GeneReviews: Not available	not available
Epidermolysis bullosa simplex 5B, with muscular dystrophy MedGen: C2931072 OMIM: 226670 GeneReviews: Epidermolysis Bullosa Simplex	not available
Epidermolysis bullosa simplex 5C, with pyloric atresia MedGen: C2677349 OMIM: 612138 GeneReviews: Epidermolysis Bullosa with Pyloric Atresia	not available
Epidermolysis bullosa simplex with nail dystrophy MedGen: C4225309 OMIM: 616487 GeneReviews: Not available	not available
Epidermolysis bullosa simplex, Ogna type MedGen: C0432317 OMIM: 131950 GeneReviews: Epidermolysis Bullosa with Pyloric Atresia	not available
Junctional epidermolysis bullosa with pyloric atresia MedGen: C5676875 OMIM: 226730 GeneReviews: Junctional Epidermolysis Bullosa, Epidermolysis Bullosa with Pyloric Atresia	not available

EBI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Discovery and refinement of loci associated with lipid levels. EBI GWAS Catalog EBI GWAS CatalogPubMed
Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
New gene functions in megakaryopoiesis and platelet formation. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	Variants of HIV-1 Vif have been shown to form perinuclear aggregates and relocalize plectin to these structures	PubMed
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of plectin (PLEC) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables dystroglycan binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of muscle	IMP Inferred from Mutant Phenotype more info	PubMed
enables structural constituent of muscle	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in actomyosin contractile ring assembly actin filament organization	IEA Inferred from Electronic Annotation more info
involved_in adherens junction organization	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cellular response to fluid shear stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hydrostatic pressure	IEA Inferred from Electronic Annotation more info
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in establishment of skin barrier	IEA Inferred from Electronic Annotation more info
involved_in fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in gene expression	IEA Inferred from Electronic Annotation more info
involved_in hemidesmosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in hemidesmosome assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in intermediate filament cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte development	IEA Inferred from Electronic Annotation more info
involved_in leukocyte migration involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in mitochondrion organization	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism growth	IEA Inferred from Electronic Annotation more info
involved_in myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in nucleus organization	IEA Inferred from Electronic Annotation more info
involved_in peripheral nervous system myelin maintenance	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of vascular permeability	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in response to food	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IEA Inferred from Electronic Annotation more info
involved_in skeletal muscle fiber development	IEA Inferred from Electronic Annotation more info
involved_in skeletal myofibril assembly	IEA Inferred from Electronic Annotation more info
involved_in tight junction organization	IEA Inferred from Electronic Annotation more info
involved_in transmission of nerve impulse	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in brush border	IEA Inferred from Electronic Annotation more info
located_in costamere	TAS Traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info
is_active_in hemidesmosome	IBA Inferred from Biological aspect of Ancestor more info
located_in hemidesmosome	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with intermediate filament	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament cytoskeleton	IDA Inferred from Direct Assay more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in myelin sheath	IEA Inferred from Electronic Annotation more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: plectin

Names: hemidesmosomal protein 1; plectin 1, intermediate filament binding protein 500kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012492.1 RefSeqGene

Range

5001..66593

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000445.5 → NP_000436.2 plectin isoform 1c

See identical proteins and their annotated locations for NP_000436.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) contains the 5'-most coding exon (exon 1c) and encodes isoform 1c.

Source sequence(s)

AY480044, BP312608

Consensus CDS

CCDS43769.1

UniProtKB/TrEMBL

E9PMV1

Related

ENSP00000388180.2, ENST00000436759.6

Conserved Domains (10) summary

smart00250
Location:3121 → 3157

PLEC; Plectin repeat

cd00014
Location:70 → 172

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:645 → 834

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:187 → 285

CH; Calponin homology (CH) domain

pfam00681
Location:4068 → 4109

Plectin; Plectin repeat

pfam01576
Location:1370 → 2493

Myosin_tail_1; Myosin tail

cd16269
Location:1470 → 1481

GBP_C; coiled coil [structural motif]

cl02488
Location:1753 → 1955

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1379 → 1506

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1505 → 1625

ATP-synt_B; ATP synthase B/B' CF(0)
NM_001410941.1 → NP_001397870.1 plectin isoform 2

Status: REVIEWED

Source sequence(s)

AC109322

Consensus CDS

CCDS94359.1

UniProtKB/TrEMBL

H0YDN1

Related

ENSP00000433982.2, ENST00000527303.2
NM_201378.4 → NP_958780.1 plectin isoform 1f

See identical proteins and their annotated locations for NP_958780.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1f) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1f has been found to be concentrated in vinculin-positive structures at actin stress fiber ends (PMID: 14559777).

Source sequence(s)

AY480045, BP315878

Consensus CDS

CCDS43770.1

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000348702.3, ENST00000356346.7

Conserved Domains (10) summary

smart00250
Location:3080 → 3116

PLEC; Plectin repeat

cd00014
Location:29 → 131

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:604 → 793

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:146 → 244

CH; Calponin homology (CH) domain

pfam00681
Location:4027 → 4068

Plectin; Plectin repeat

pfam01576
Location:1329 → 2452

Myosin_tail_1; Myosin tail

cd16269
Location:1429 → 1440

GBP_C; coiled coil [structural motif]

cl02488
Location:1712 → 1914

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1338 → 1465

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1464 → 1584

ATP-synt_B; ATP synthase B/B' CF(0)
NM_201379.3 → NP_958781.1 plectin isoform 1e

See identical proteins and their annotated locations for NP_958781.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1e) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

AY480046

Consensus CDS

CCDS43771.1

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000347044.2, ENST00000354958.6

Conserved Domains (10) summary

smart00250
Location:3072 → 3108

PLEC; Plectin repeat

cd00014
Location:21 → 123

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:596 → 785

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:138 → 236

CH; Calponin homology (CH) domain

pfam00681
Location:4019 → 4060

Plectin; Plectin repeat

pfam01576
Location:1321 → 2444

Myosin_tail_1; Myosin tail

cd16269
Location:1421 → 1432

GBP_C; coiled coil [structural motif]

cl02488
Location:1704 → 1906

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1330 → 1457

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1456 → 1576

ATP-synt_B; ATP synthase B/B' CF(0)
NM_201380.4 → NP_958782.1 plectin isoform 1

See identical proteins and their annotated locations for NP_958782.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

AC109322, AY480047

Consensus CDS

CCDS43772.1

UniProtKB/Swiss-Prot

Q15148, Q15149, Q16640, Q6S376, Q6S377, Q6S378, Q6S379, Q6S380, Q6S381, Q6S382, Q6S383

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000323856.4, ENST00000322810.8

Conserved Domains (11) summary

smart00250
Location:3231 → 3267

PLEC; Plectin repeat

cd00014
Location:180 → 282

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:755 → 944

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:297 → 395

CH; Calponin homology (CH) domain

pfam00681
Location:4178 → 4219

Plectin; Plectin repeat

pfam01576
Location:1480 → 2603

Myosin_tail_1; Myosin tail

pfam03501
Location:7 → 101

S10_plectin; Plectin/S10 domain

cd16269
Location:1580 → 1591

GBP_C; coiled coil [structural motif]

cl02488
Location:1863 → 2065

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1489 → 1616

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1615 → 1735

ATP-synt_B; ATP synthase B/B' CF(0)
NM_201381.3 → NP_958783.1 plectin isoform 1d

See identical proteins and their annotated locations for NP_958783.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1d) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1d has been found associated with Z-disks in skeletal muscle (PMID: 17389230).

Source sequence(s)

AC109322, AY480048

Consensus CDS

CCDS47936.1

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000381756.2, ENST00000398774.6

Conserved Domains (10) summary

smart00250
Location:3062 → 3098

PLEC; Plectin repeat

cd00014
Location:11 → 113

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:586 → 775

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:128 → 226

CH; Calponin homology (CH) domain

pfam00681
Location:4009 → 4050

Plectin; Plectin repeat

pfam01576
Location:1311 → 2434

Myosin_tail_1; Myosin tail

cd16269
Location:1411 → 1422

GBP_C; coiled coil [structural motif]

cl02488
Location:1694 → 1896

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1320 → 1447

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1446 → 1566

ATP-synt_B; ATP synthase B/B' CF(0)
NM_201382.4 → NP_958784.1 plectin isoform 1b

See identical proteins and their annotated locations for NP_958784.1

Status: REVIEWED

Description

Transcript Variant: This variant (8) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1b) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1b has been found to associate exclusively with mitochondria (PMID: 18541706, 14559777).

Source sequence(s)

AC109322, AY480049, BP231761

Consensus CDS

CCDS43773.1

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000346602.3, ENST00000354589.7

Conserved Domains (10) summary

smart00250
Location:3094 → 3130

PLEC; Plectin repeat

cd00014
Location:43 → 145

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:618 → 807

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:160 → 258

CH; Calponin homology (CH) domain

pfam00681
Location:4041 → 4082

Plectin; Plectin repeat

pfam01576
Location:1343 → 2466

Myosin_tail_1; Myosin tail

cd16269
Location:1443 → 1454

GBP_C; coiled coil [structural motif]

cl02488
Location:1726 → 1928

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1352 → 1479

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1478 → 1598

ATP-synt_B; ATP synthase B/B' CF(0)
NM_201383.3 → NP_958785.1 plectin isoform 1g

See identical proteins and their annotated locations for NP_958785.1

Status: REVIEWED

Description

Transcript Variant: This variant (10) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1g) contains a distinct N-terminus compared to isoform 1c.

Source sequence(s)

AC109322, AY480050

Consensus CDS

CCDS43774.1

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000350277.2, ENST00000357649.6

Conserved Domains (10) summary

smart00250
Location:3098 → 3134

PLEC; Plectin repeat

cd00014
Location:47 → 149

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:622 → 811

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:164 → 262

CH; Calponin homology (CH) domain

pfam00681
Location:4045 → 4086

Plectin; Plectin repeat

pfam01576
Location:1347 → 2470

Myosin_tail_1; Myosin tail

cd16269
Location:1447 → 1458

GBP_C; coiled coil [structural motif]

cl02488
Location:1730 → 1932

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1356 → 1483

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1482 → 1602

ATP-synt_B; ATP synthase B/B' CF(0)
NM_201384.3 → NP_958786.1 plectin isoform 1a

See identical proteins and their annotated locations for NP_958786.1

Status: REVIEWED

Description

Transcript Variant: This variant (11) differs in the 5' UTR and the 5' coding region compared to variant 1. The resulting protein (isoform 1a) contains a distinct N-terminus compared to isoform 1c. Plectin isoform 1a has been found to associate specifically with hemidesmosome-like structures in keratinocytes (PMID: 12542521).

Source sequence(s)

AC109322, AY480051

Consensus CDS

CCDS43775.1

UniProtKB/TrEMBL

A0A8I5KYZ1

Related

ENSP00000344848.3, ENST00000345136.8

Conserved Domains (10) summary

smart00250
Location:3094 → 3130

PLEC; Plectin repeat

cd00014
Location:43 → 145

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:618 → 807

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:160 → 258

CH; Calponin homology (CH) domain

pfam00681
Location:4041 → 4082

Plectin; Plectin repeat

pfam01576
Location:1343 → 2466

Myosin_tail_1; Myosin tail

cd16269
Location:1443 → 1454

GBP_C; coiled coil [structural motif]

cl02488
Location:1726 → 1928

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1352 → 1479

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1478 → 1598

ATP-synt_B; ATP synthase B/B' CF(0)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

143915153..143976745 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421872.1 → XP_047277828.1 plectin isoform X7

UniProtKB/TrEMBL

E9PMV1

Related

ENSP00000434583.1, ENST00000527096.5
XM_006716588.4 → XP_006716651.1 plectin isoform X6

UniProtKB/TrEMBL

E9PMV1

Related

ENSP00000437303.2, ENST00000528025.6

Conserved Domains (10) summary

smart00250
Location:3126 → 3162

PLEC; Plectin repeat

cd00014
Location:70 → 177

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:650 → 839

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:192 → 290

CH; Calponin homology (CH) domain

pfam00681
Location:4073 → 4114

Plectin; Plectin repeat

pfam01576
Location:1375 → 2498

Myosin_tail_1; Myosin tail

cd16269
Location:1475 → 1486

GBP_C; coiled coil [structural motif]

cl02488
Location:1758 → 1960

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1384 → 1511

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1510 → 1630

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421890.1 → XP_047277846.1 plectin isoform X32
XM_047421875.1 → XP_047277831.1 plectin isoform X14

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_047421889.1 → XP_047277845.1 plectin isoform X31
XM_005250981.4 → XP_005251038.1 plectin isoform X12

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3085 → 3121

PLEC; Plectin repeat

cd00014
Location:29 → 136

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:609 → 798

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:151 → 249

CH; Calponin homology (CH) domain

pfam00681
Location:4032 → 4073

Plectin; Plectin repeat

pfam01576
Location:1334 → 2457

Myosin_tail_1; Myosin tail

cd16269
Location:1434 → 1445

GBP_C; coiled coil [structural motif]

cl02488
Location:1717 → 1919

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1343 → 1470

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1469 → 1589

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421893.1 → XP_047277849.1 plectin isoform X35
XM_047421877.1 → XP_047277833.1 plectin isoform X19

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_047421891.1 → XP_047277847.1 plectin isoform X33
XM_005250982.5 → XP_005251039.1 plectin isoform X13

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3077 → 3113

PLEC; Plectin repeat

cd00014
Location:21 → 128

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:601 → 790

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:143 → 241

CH; Calponin homology (CH) domain

pfam00681
Location:4024 → 4065

Plectin; Plectin repeat

pfam01576
Location:1326 → 2449

Myosin_tail_1; Myosin tail

cd16269
Location:1426 → 1437

GBP_C; coiled coil [structural motif]

cl02488
Location:1709 → 1911

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1335 → 1462

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1461 → 1581

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421884.1 → XP_047277840.1 plectin isoform X27
XM_047421870.1 → XP_047277826.1 plectin isoform X5

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_047421882.1 → XP_047277838.1 plectin isoform X26
XM_005250976.5 → XP_005251033.1 plectin isoform X4

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (11) summary

smart00250
Location:3236 → 3272

PLEC; Plectin repeat

cd00014
Location:180 → 287

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:760 → 949

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:302 → 400

CH; Calponin homology (CH) domain

pfam00681
Location:4183 → 4224

Plectin; Plectin repeat

pfam01576
Location:1485 → 2608

Myosin_tail_1; Myosin tail

pfam03501
Location:7 → 101

S10_plectin; Plectin/S10 domain

cd16269
Location:1585 → 1596

GBP_C; coiled coil [structural motif]

cl02488
Location:1868 → 2070

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1494 → 1621

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1620 → 1740

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421895.1 → XP_047277851.1 plectin isoform X36
XM_047421878.1 → XP_047277834.1 plectin isoform X20

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_047421892.1 → XP_047277848.1 plectin isoform X34
XM_005250983.3 → XP_005251040.1 plectin isoform X18

UniProtKB/TrEMBL

A0A8I5KUE3, A0A8I5KYZ1

Related

ENSP00000510329.1, ENST00000693060.1

Conserved Domains (10) summary

smart00250
Location:3071 → 3107

PLEC; Plectin repeat

cd00014
Location:20 → 122

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:595 → 784

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:137 → 235

CH; Calponin homology (CH) domain

pfam00681
Location:4018 → 4059

Plectin; Plectin repeat

pfam01576
Location:1320 → 2443

Myosin_tail_1; Myosin tail

cd16269
Location:1420 → 1431

GBP_C; coiled coil [structural motif]

cl02488
Location:1703 → 1905

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1329 → 1456

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1455 → 1575

ATP-synt_B; ATP synthase B/B' CF(0)
XM_006716589.3 → XP_006716652.1 plectin isoform X15

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3076 → 3112

PLEC; Plectin repeat

cd00014
Location:20 → 127

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:600 → 789

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:142 → 240

CH; Calponin homology (CH) domain

pfam00681
Location:4023 → 4064

Plectin; Plectin repeat

pfam01576
Location:1325 → 2448

Myosin_tail_1; Myosin tail

cd16269
Location:1425 → 1436

GBP_C; coiled coil [structural motif]

cl02488
Location:1708 → 1910

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1334 → 1461

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1460 → 1580

ATP-synt_B; ATP synthase B/B' CF(0)
XM_005250984.6 → XP_005251041.1 plectin isoform X21

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3067 → 3103

PLEC; Plectin repeat

cd00014
Location:11 → 118

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:591 → 780

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:133 → 231

CH; Calponin homology (CH) domain

pfam00681
Location:4014 → 4055

Plectin; Plectin repeat

pfam01576
Location:1316 → 2439

Myosin_tail_1; Myosin tail

cd16269
Location:1416 → 1427

GBP_C; coiled coil [structural motif]

cl02488
Location:1699 → 1901

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1325 → 1452

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1451 → 1571

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421888.1 → XP_047277844.1 plectin isoform X30
XM_047421874.1 → XP_047277830.1 plectin isoform X11

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_005250979.5 → XP_005251036.1 plectin isoform X8

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3099 → 3135

PLEC; Plectin repeat

cd00014
Location:43 → 150

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:623 → 812

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:165 → 263

CH; Calponin homology (CH) domain

pfam00681
Location:4046 → 4087

Plectin; Plectin repeat

pfam01576
Location:1348 → 2471

Myosin_tail_1; Myosin tail

cd16269
Location:1448 → 1459

GBP_C; coiled coil [structural motif]

cl02488
Location:1731 → 1933

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1357 → 1484

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1483 → 1603

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421881.1 → XP_047277837.1 plectin isoform X25
XM_047421869.1 → XP_047277825.1 plectin isoform X3

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_047421880.1 → XP_047277836.1 plectin isoform X24
XM_011517130.3 → XP_011515432.1 plectin isoform X2

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3099 → 3135

PLEC; Plectin repeat

cd00014
Location:47 → 154

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:623 → 812

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:169 → 267

CH; Calponin homology (CH) domain

pfam00681
Location:4046 → 4087

Plectin; Plectin repeat

pfam01576
Location:1348 → 2471

Myosin_tail_1; Myosin tail

cd16269
Location:1448 → 1459

GBP_C; coiled coil [structural motif]

cl02488
Location:1731 → 1933

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1357 → 1484

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1483 → 1603

ATP-synt_B; ATP synthase B/B' CF(0)
XM_011517132.3 → XP_011515434.1 plectin isoform X23

Conserved Domains (5) summary

smart00250
Location:1976 → 2012

PLEC; Plectin repeat

cd00014
Location:47 → 154

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:627 → 816

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:169 → 267

CH; Calponin homology (CH) domain

pfam00681
Location:2923 → 2964

Plectin; Plectin repeat
XM_005250978.4 → XP_005251035.1 plectin isoform X1

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3103 → 3139

PLEC; Plectin repeat

cd00014
Location:47 → 154

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:627 → 816

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:169 → 267

CH; Calponin homology (CH) domain

pfam00681
Location:4050 → 4091

Plectin; Plectin repeat

pfam01576
Location:1352 → 2475

Myosin_tail_1; Myosin tail

cd16269
Location:1452 → 1463

GBP_C; coiled coil [structural motif]

cl02488
Location:1735 → 1937

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1361 → 1488

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1487 → 1607

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421887.1 → XP_047277843.1 plectin isoform X29
XM_047421873.1 → XP_047277829.1 plectin isoform X10

UniProtKB/TrEMBL

A0A8I5KYZ1
XM_047421886.1 → XP_047277842.1 plectin isoform X28
XM_005250980.5 → XP_005251037.1 plectin isoform X9

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3099 → 3135

PLEC; Plectin repeat

cd00014
Location:43 → 150

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:623 → 812

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:165 → 263

CH; Calponin homology (CH) domain

pfam00681
Location:4046 → 4087

Plectin; Plectin repeat

pfam01576
Location:1348 → 2471

Myosin_tail_1; Myosin tail

cd16269
Location:1448 → 1459

GBP_C; coiled coil [structural motif]

cl02488
Location:1731 → 1933

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1357 → 1484

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1483 → 1603

ATP-synt_B; ATP synthase B/B' CF(0)
XM_011517131.3 → XP_011515433.1 plectin isoform X17

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3071 → 3107

PLEC; Plectin repeat

cd00014
Location:20 → 122

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:595 → 784

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:137 → 235

CH; Calponin homology (CH) domain

pfam00681
Location:4018 → 4059

Plectin; Plectin repeat

pfam01576
Location:1320 → 2443

Myosin_tail_1; Myosin tail

cd16269
Location:1420 → 1431

GBP_C; coiled coil [structural motif]

cl02488
Location:1703 → 1905

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1329 → 1456

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1455 → 1575

ATP-synt_B; ATP synthase B/B' CF(0)
XM_006716590.4 → XP_006716653.1 plectin isoform X16

UniProtKB/TrEMBL

A0A8I5KYZ1

Conserved Domains (10) summary

smart00250
Location:3076 → 3112

PLEC; Plectin repeat

cd00014
Location:20 → 127

CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...

cd00176
Location:600 → 789

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

pfam00307
Location:142 → 240

CH; Calponin homology (CH) domain

pfam00681
Location:4023 → 4064

Plectin; Plectin repeat

pfam01576
Location:1325 → 2448

Myosin_tail_1; Myosin tail

cd16269
Location:1425 → 1436

GBP_C; coiled coil [structural motif]

cl02488
Location:1708 → 1910

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl20817
Location:1334 → 1461

GBP_C; Guanylate-binding protein, C-terminal domain

cl21478
Location:1460 → 1580

ATP-synt_B; ATP synthase B/B' CF(0)
XM_047421879.1 → XP_047277835.1 plectin isoform X22

UniProtKB/TrEMBL

A0A8I5KSD5, A0A8I5KYZ1

Related

ENSP00000510788.1, ENST00000687971.1