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    DDAH2 DDAH family member 2, ADMA-independent [ Homo sapiens (human) ]

    Gene ID: 23564, updated on 3-Dec-2024

    Summary

    Official Symbol
    DDAH2provided by HGNC
    Official Full Name
    DDAH family member 2, ADMA-independentprovided by HGNC
    Primary source
    HGNC:HGNC:2716
    See related
    Ensembl:ENSG00000213722 MIM:604744; AllianceGenome:HGNC:2716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    G6a; DDAH; NG30; DDAHII; HEL-S-277
    Summary
    This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be localized to the mitochondria. Alternative splicing resulting in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in endometrium (RPKM 29.0), fat (RPKM 28.2) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See DDAH2 in Genome Data Viewer
    Location:
    6p21.33
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (31727040..31730263, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (31580073..31583296, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (31694817..31698040, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LY6G6F-LY6G6D readthrough Neighboring gene lymphocyte antigen 6 family member G6D Neighboring gene lymphocyte antigen 6 family member G6C Neighboring gene megakaryocyte and platelet inhibitory receptor G6b Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:31701615-31702814 Neighboring gene chloride intracellular channel 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31704508-31705382 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31707224-31707854 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:31707855-31708486 Neighboring gene MSH5-SAPCD1 readthrough (NMD candidate) Neighboring gene mutS homolog 5 Neighboring gene RNA, U6 small nuclear 850, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    putative hydrolase DDAH2
    Names
    S-phase protein
    dimethylargininase-2
    dimethylarginine dimethylaminohydrolase 2
    dimethylarginine dimethylaminohydrolase II
    epididymis secretory protein Li 277
    inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2
    inactive dimethylarginine dimethylaminohydrolase 2
    n(G),N(G)-dimethylarginine dimethylaminohydrolase 2
    testis tissue sperm-binding protein Li 54e
    NP_001289936.1
    NP_001289937.1
    NP_039268.1
    XP_011512750.1
    XP_054185725.1
    XP_054186217.1
    XP_054186508.1
    XP_054186760.1
    XP_054186997.1
    XP_054187263.1
    XP_054210944.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303007.2NP_001289936.1  putative hydrolase DDAH2

      See identical proteins and their annotated locations for NP_001289936.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK026191
      Consensus CDS
      CCDS4718.1
      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53
      Related
      ENSP00000364945.2, ENST00000375789.7
      Conserved Domains (1) summary
      cl19186
      Location:62277
      Amidinotransf; Amidinotransferase
    2. NM_001303008.2NP_001289937.1  putative hydrolase DDAH2

      See identical proteins and their annotated locations for NP_001289937.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AL662899, BF338733, CB242623, EB387244
      Consensus CDS
      CCDS4718.1
      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53
      Related
      ENSP00000395759.2, ENST00000436437.2
      Conserved Domains (1) summary
      cl19186
      Location:62277
      Amidinotransf; Amidinotransferase
    3. NM_013974.3NP_039268.1  putative hydrolase DDAH2

      See identical proteins and their annotated locations for NP_039268.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment of the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AA297871, AF070667, AK310024, CB242623
      Consensus CDS
      CCDS4718.1
      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53
      Related
      ENSP00000364949.3, ENST00000375792.7
      Conserved Domains (1) summary
      cl19186
      Location:62277
      Amidinotransf; Amidinotransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      31727040..31730263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514448.3XP_011512750.1  putative hydrolase DDAH2 isoform X1

      See identical proteins and their annotated locations for XP_011512750.1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53
      Related
      ENSP00000397466.2, ENST00000416410.6
      Conserved Domains (1) summary
      cl19186
      Location:62277
      Amidinotransf; Amidinotransferase

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_113891.3 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      3204328..3207551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329750.1XP_054185725.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53

    Reference GRCh38.p14 ALT_REF_LOCI_3

    Genomic

    1. NT_167245.2 Reference GRCh38.p14 ALT_REF_LOCI_3

      Range
      2974801..2978024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330242.1XP_054186217.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53

    Reference GRCh38.p14 ALT_REF_LOCI_4

    Genomic

    1. NT_167246.2 Reference GRCh38.p14 ALT_REF_LOCI_4

      Range
      3032087..3035310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330533.1XP_054186508.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53

    Reference GRCh38.p14 ALT_REF_LOCI_5

    Genomic

    1. NT_167247.2 Reference GRCh38.p14 ALT_REF_LOCI_5

      Range
      3068915..3072138 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054330785.1XP_054186760.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53

    Reference GRCh38.p14 ALT_REF_LOCI_6

    Genomic

    1. NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

      Range
      2982851..2986074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331022.1XP_054186997.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53

    Reference GRCh38.p14 ALT_REF_LOCI_7

    Genomic

    1. NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

      Range
      3026336..3029559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331288.1XP_054187263.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      31580073..31583296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354969.1XP_054210944.1  putative hydrolase DDAH2 isoform X1

      UniProtKB/Swiss-Prot
      A2BEZ7, O95865
      UniProtKB/TrEMBL
      Q5SRR8, V9HW53