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    Arl2 ADP-ribosylation factor-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 56327, updated on 4-Jan-2025

    Summary

    Official Symbol
    Arl2provided by MGI
    Official Full Name
    ADP-ribosylation factor-like 2provided by MGI
    Primary source
    MGI:MGI:1928393
    See related
    Ensembl:ENSMUSG00000024944 AllianceGenome:MGI:1928393
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610009M23Rik
    Summary
    Enables GDP binding activity and GTP binding activity. Predicted to be involved in several processes, including bicellular tight junction assembly; negative regulation of GTPase activity; and regulation of generation of precursor metabolites and energy. Located in cytoplasm. Orthologous to human ARL2 (ARF like GTPase 2). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 136.8), mammary gland adult (RPKM 70.2) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Arl2 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6184419..6191167, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6134389..6141137, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene SAC3 domain containing 1 Neighboring gene sorting nexin 15 Neighboring gene STARR-positive B cell enhancer ABC_E11014 Neighboring gene predicted gene, 57660 Neighboring gene microRNA 12193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6141140-6141385 Neighboring gene predicted pseudogene 5510 Neighboring gene basic leucine zipper transcription factor, ATF-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GDP binding PubMed 
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables protein binding PubMed 
    Process Evidence Code Pubs
    involved_in acetylcholine transport  
    involved_in bicellular tight junction assembly  
    involved_in centrosome cycle  
    involved_in centrosome cycle  
    involved_in maintenance of protein location in nucleus  
    involved_in maintenance of protein location in nucleus  
    involved_in negative regulation of GTPase activity  
    involved_in negative regulation of GTPase activity  
    involved_in positive regulation of cell-substrate adhesion  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of microtubule polymerization  
    involved_in protein folding  
    involved_in regulation of aerobic respiration  
    involved_in regulation of aerobic respiration  
    involved_in regulation of glycolytic process  
    involved_in regulation of glycolytic process  
    involved_in regulation of microtubule polymerization  
    involved_in regulation of microtubule polymerization  
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in centrosome  
    located_in centrosome  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in lateral plasma membrane  
    is_active_in microtubule cytoskeleton  
    located_in mitochondrial intermembrane space  
    located_in mitochondrial intermembrane space  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    ADP-ribosylation factor-like protein 2
    Names
    ADP-ribosylation-like 2
    arf-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019722.3NP_062696.2  ADP-ribosylation factor-like protein 2

      See identical proteins and their annotated locations for NP_062696.2

      Status: VALIDATED

      Source sequence(s)
      AK011366
      Consensus CDS
      CCDS29496.1
      UniProtKB/Swiss-Prot
      Q9D0J4, Q9WUM1
      Related
      ENSMUSP00000025893.6, ENSMUST00000025893.7
      Conserved Domains (1) summary
      cd04154
      Location:3175
      Arl2; Arf-like 2 (Arl2) GTPase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6184419..6191167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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