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    Pagr1a PAXIP1 associated glutamate rich protein 1A [ Mus musculus (house mouse) ]

    Gene ID: 67278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pagr1aprovided by MGI
    Official Full Name
    PAXIP1 associated glutamate rich protein 1Aprovided by MGI
    Primary source
    MGI:MGI:1914528
    See related
    Ensembl:ENSMUSG00000107068 AllianceGenome:MGI:1914528
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PA1; PAGR1; 2900092E17Rik
    Summary
    Predicted to enable nuclear estrogen receptor binding activity. Involved in DNA damage response; positive regulation of isotype switching to IgG isotypes; and regulation of cell cycle G2/M phase transition. Acts upstream of or within chorion development. Part of histone methyltransferase complex. Is expressed in several structures, including extraembryonic component. Orthologous to human PAGR1 (PAXIP1 associated glutamate rich protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 90.4), CNS E11.5 (RPKM 43.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pagr1a in Genome Data Viewer
    Location:
    7 F3; 7 69.27 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126614223..126616524, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127015051..127017352, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene major vault protein Neighboring gene STARR-seq mESC enhancer starr_20161 Neighboring gene STARR-positive B cell enhancer ABC_E2850 Neighboring gene proline-rich transmembrane protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134167876-134168063 Neighboring gene predicted gene, 53372 Neighboring gene MYC-associated zinc finger protein (purine-binding transcription factor)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ. Lee JE, et al. Mol Cell Biol, 2020 Aug 14. PMID 32601106, Free PMC Article
    2. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Starnes LM, et al. Genes Dev, 2016 Jan 15. PMID 26744420, Free PMC Article
    3. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. Gong Z, et al. J Biol Chem, 2009 Mar 13. PMID 19124460, Free PMC Article
    4. UTX regulates mesoderm differentiation of embryonic stem cells independent of H3K27 demethylase activity. Wang C, et al. Proc Natl Acad Sci U S A, 2012 Sep 18. PMID 22949634, Free PMC Article
    5. Loss of function of mouse Pax-Interacting Protein 1-associated glutamate rich protein 1a (Pagr1a) leads to reduced Bmp2 expression and defects in chorion and amnion development. Kumar A, et al. Dev Dyn, 2014 Jul. PMID 24633704, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPbeta and C/EBPdelta.
      Title: MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.
    2. a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR
      Title: A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.
    3. subset of PTIP.PA1 complex is recruited to DNA damage sites via the RNF8-dependent pathway and is required for cell survival in response to DNA damage.
      Title: Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage.
    4. PA1 (also known as C16orf53 in human and 2900092E17Rik in mouse) binds PTIP directly and requires PTIP for interaction with the MLL3- and MLL4-containing histone H3 K4 methyltransferase complex.
      Title: PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nuclear estrogen receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chorion development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle G1/S phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cell cycle G1/S phase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of intracellular estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle G2/M phase transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MLL3/4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MLL3/4 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone methyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    PAXIP1-associated glutamate-rich protein 1A
    Names
    PAXIP1-associated glutamate-rich protein 1
    PAXIP1-associated protein 1
    PTIP-associated 1
    PTIP-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030240.1 → NP_084516.1  PAXIP1-associated glutamate-rich protein 1A

      See identical proteins and their annotated locations for NP_084516.1

      Status: PROVISIONAL

      Source sequence(s)
      BC003932
      Consensus CDS
      CCDS21854.1
      UniProtKB/Swiss-Prot
      Q99L02
      Related
      ENSMUSP00000144243.2, ENSMUST00000202798.2
      Conserved Domains (1) summary
      pfam15364
      Location:85 → 216
      PAXIP1_C; PAXIP1-associated-protein-1 C term PTIP binding protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126614223..126616524 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L02.1 GenPept UniProtKB/Swiss-Prot:Q99L02

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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