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    Adck2 aarF domain containing kinase 2 [ Mus musculus (house mouse) ]

    Gene ID: 57869, updated on 9-Dec-2024

    Summary

    Official Symbol
    Adck2provided by MGI
    Official Full Name
    aarF domain containing kinase 2provided by MGI
    Primary source
    MGI:MGI:1889336
    See related
    Ensembl:ENSMUSG00000046947 AllianceGenome:MGI:1889336
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Involved in regulation of ubiquinone biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Used to study mitochondrial myopathy. Orthologous to human ADCK2 (aarF domain containing kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 10.2), ovary adult (RPKM 9.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Adck2 in Genome Data Viewer
    Location:
    6 B1; 6 18.39 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (39550778..39565703)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (39573844..39588769)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene DENN domain containing 2A Neighboring gene predicted gene, 52860 Neighboring gene STARR-seq mESC enhancer starr_15661 Neighboring gene RIKEN cDNA 8030453O22 gene Neighboring gene VISTA enhancer mm1321 Neighboring gene NADH:ubiquinone oxidoreductase subunit B2 Neighboring gene Braf transforming gene Neighboring gene predicted gene, 34389

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding  
    enables molecular_function  
    enables protein serine/threonine kinase activity  
    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion PubMed 
    located_in mitochondrion  

    General protein information

    Preferred Names
    uncharacterized aarF domain-containing protein kinase 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178873.3NP_849204.1  uncharacterized aarF domain-containing protein kinase 2

      See identical proteins and their annotated locations for NP_849204.1

      Status: PROVISIONAL

      Source sequence(s)
      AK028568
      Consensus CDS
      CCDS20024.1
      UniProtKB/Swiss-Prot
      Q3TTS5, Q6NSR3, Q8BHC6
      UniProtKB/TrEMBL
      A0A0R4J1X6
      Related
      ENSMUSP00000123563.2, ENSMUST00000140364.8
      Conserved Domains (2) summary
      cd13971
      Location:169544
      ADCK2-like; aarF domain containing kinase 2 and similar proteins
      TIGR01982
      Location:98609
      UbiB; 2-polyprenylphenol 6-hydroxylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      39550778..39565703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506425.3XP_006506488.1  uncharacterized aarF domain-containing protein kinase 2 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:169430
      PKc_like; Protein Kinases, catalytic domain
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