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    Ppp3ca protein phosphatase 3, catalytic subunit, alpha isoform [ Mus musculus (house mouse) ]

    Gene ID: 19055, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ppp3caprovided by MGI
    Official Full Name
    protein phosphatase 3, catalytic subunit, alpha isoformprovided by MGI
    Primary source
    MGI:MGI:107164
    See related
    Ensembl:ENSMUSG00000028161 AllianceGenome:MGI:107164
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CN; CnA; Caln; Calna; 2900074D19Rik
    Summary
    Enables calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of transport; and regulation of gene expression. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; calcineurin-NFAT signaling cascade; and regulation of DNA-templated transcription. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut gland; jaw; and thymus primordium. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 101.0), frontal lobe adult (RPKM 75.5) and 17 other tissues See more
    Orthologs
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    Genomic context

    See Ppp3ca in Genome Data Viewer
    Location:
    3 G3; 3 63.34 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (136375778..136643488)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (136669714..136937727)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11221 Neighboring gene STARR-seq mESC enhancer starr_09074 Neighboring gene heat shock protein 90 alpha (cytosolic), class B member 1 pseudogene Neighboring gene RIKEN cDNA 1700030L20 gene Neighboring gene STARR-positive B cell enhancer ABC_E1635 Neighboring gene STARR-positive B cell enhancer ABC_E11222 Neighboring gene STARR-seq mESC enhancer starr_09075 Neighboring gene STARR-positive B cell enhancer ABC_E6136 Neighboring gene STARR-seq mESC enhancer starr_09076 Neighboring gene STARR-positive B cell enhancer ABC_E6137 Neighboring gene STARR-seq mESC enhancer starr_09078 Neighboring gene STARR-seq mESC enhancer starr_09079 Neighboring gene RIKEN cDNA 1700006H20 gene Neighboring gene 60S ribosomal protein L36a-like Neighboring gene STARR-seq mESC enhancer starr_09082 Neighboring gene predicted gene, 26107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC106804

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables ATPase binding  
    enables ATPase binding  
    enables MAP kinase serine/threonine phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity  
    enables calcium-dependent protein serine/threonine phosphatase activity  
    enables calcium-dependent protein serine/threonine phosphatase activity  
    enables calmodulin binding  
    enables calmodulin binding PubMed 
    enables calmodulin binding  
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity PubMed 
    enables calmodulin-dependent protein phosphatase activity  
    enables calmodulin-dependent protein phosphatase activity  
    enables cyclosporin A binding  
    enables enzyme binding  
    enables histone H2AXS140 phosphatase activity  
    enables metal ion binding  
    enables myosin phosphatase activity  
    enables phosphoprotein phosphatase activity PubMed 
    enables phosphoprotein phosphatase activity  
    enables protein binding PubMed 
    enables protein dimerization activity  
    enables protein dimerization activity  
    enables protein serine/threonine phosphatase activity  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 67
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1/S transition of mitotic cell cycle PubMed 
    involved_in calcineurin-NFAT signaling cascade  
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade PubMed 
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade PubMed 
    acts_upstream_of_or_within calcineurin-NFAT signaling cascade PubMed 
    involved_in calcineurin-NFAT signaling cascade  
    involved_in calcineurin-mediated signaling  
    acts_upstream_of_or_within calcium ion transport PubMed 
    acts_upstream_of_or_within calcium-mediated signaling PubMed 
    acts_upstream_of_or_within cardiac muscle hypertrophy in response to stress PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to glucose stimulus  
    involved_in chromatin remodeling  
    acts_upstream_of dendrite morphogenesis PubMed 
    acts_upstream_of_or_within dephosphorylation PubMed 
    involved_in epidermis development PubMed 
    acts_upstream_of_or_within excitatory postsynaptic potential PubMed 
    involved_in keratinocyte differentiation PubMed 
    acts_upstream_of_or_within modulation of chemical synaptic transmission PubMed 
    involved_in modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within multicellular organismal response to stress PubMed 
    involved_in negative regulation of angiotensin-activated signaling pathway  
    involved_in negative regulation of angiotensin-activated signaling pathway  
    involved_in negative regulation of calcium ion import across plasma membrane PubMed 
    acts_upstream_of_or_within negative regulation of chromatin binding PubMed 
    acts_upstream_of_or_within negative regulation of dendrite morphogenesis PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of insulin secretion  
    involved_in negative regulation of insulin secretion  
    involved_in negative regulation of signaling PubMed 
    involved_in peptidyl-serine dephosphorylation  
    acts_upstream_of_or_within positive regulation of DNA-binding transcription factor activity PubMed 
    involved_in positive regulation of activated T cell proliferation PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade PubMed 
    involved_in positive regulation of calcium ion import across plasma membrane PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy PubMed 
    involved_in positive regulation of cardiac muscle hypertrophy in response to stress PubMed 
    involved_in positive regulation of cell adhesion  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of connective tissue replacement PubMed 
    involved_in positive regulation of endocytosis PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of glomerulus development PubMed 
    involved_in positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of osteoclast differentiation PubMed 
    involved_in positive regulation of saliva secretion PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission PubMed 
    involved_in protein dephosphorylation PubMed 
    acts_upstream_of_or_within protein dephosphorylation PubMed 
    involved_in protein dephosphorylation  
    acts_upstream_of_or_within protein import into nucleus PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    involved_in protein import into nucleus  
    involved_in regulation of cell proliferation involved in kidney morphogenesis PubMed 
    involved_in renal filtration PubMed 
    involved_in response to amphetamine  
    involved_in response to calcium ion  
    involved_in response to calcium ion  
    acts_upstream_of_or_within skeletal muscle fiber development PubMed 
    involved_in skeletal muscle fiber development PubMed 
    acts_upstream_of_or_within transition between fast and slow fiber PubMed 
    Items 1 - 25 of 67
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in Z disc PubMed 
    part_of calcineurin complex  
    part_of calcineurin complex PubMed 
    part_of calcineurin complex  
    part_of calcineurin complex PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic side of plasma membrane  
    colocalizes_with cytoplasmic side of plasma membrane  
    is_active_in cytosol  
    located_in cytosol PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in dendritic spine  
    located_in dendritic spine  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in mitochondrion PubMed 
    located_in nucleus PubMed 
    located_in plasma membrane  
    part_of protein serine/threonine phosphatase complex PubMed 
    located_in sarcolemma  
    located_in slit diaphragm  
    located_in slit diaphragm  
    is_active_in synapse  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    protein phosphatase 3 catalytic subunit alpha
    Names
    CAM-PRP catalytic subunit
    CNA alpha
    PP2B alpha 1
    PP2BA alpha
    calcineurin A alpha
    NP_001280551.1
    NP_032939.1
    XP_017174981.1
    XP_017174982.1
    XP_030108322.1
    XP_030108323.1
    XP_030108324.1
    XP_036018837.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293622.2NP_001280551.1  protein phosphatase 3 catalytic subunit alpha isoform 2

      See identical proteins and their annotated locations for NP_001280551.1

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC129775
      Consensus CDS
      CCDS80027.1
      UniProtKB/Swiss-Prot
      P63328
      Related
      ENSMUSP00000071040.8, ENSMUST00000070198.14
      Conserved Domains (1) summary
      cd07416
      Location:41345
      MPP_PP2B; PP2B, metallophosphatase domain
    2. NM_001428644.1NP_001415573.1  protein phosphatase 3 catalytic subunit alpha isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC127681, AC129775
    3. NM_001428645.1NP_001415574.1  protein phosphatase 3 catalytic subunit alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC127681, AC129775
    4. NM_001428646.1NP_001415575.1  protein phosphatase 3 catalytic subunit alpha isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC127681, AC129775
    5. NM_008913.6NP_032939.1  protein phosphatase 3 catalytic subunit alpha isoform 1

      See identical proteins and their annotated locations for NP_032939.1

      Status: VALIDATED

      Source sequence(s)
      AC116384, AC124177, AC129775
      Consensus CDS
      CCDS17860.1
      UniProtKB/Swiss-Prot
      B2RRX2, P12816, P20652, P63328, Q3UCU1, Q64135
      Related
      ENSMUSP00000053101.9, ENSMUST00000056758.9
      Conserved Domains (1) summary
      cd07416
      Location:41345
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      136375778..136643488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252463.2XP_030108323.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    2. XM_030252464.2XP_030108324.1  protein phosphatase 3 catalytic subunit alpha isoform X2

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    3. XM_030252462.2XP_030108322.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    4. XM_017319493.3XP_017174982.1  protein phosphatase 3 catalytic subunit alpha isoform X2

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    5. XM_036162944.1XP_036018837.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
    6. XM_017319492.3XP_017174981.1  protein phosphatase 3 catalytic subunit alpha isoform X1

      Conserved Domains (1) summary
      cd07416
      Location:1295
      MPP_PP2B; PP2B, metallophosphatase domain
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