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    Lgals12 lectin, galactose binding, soluble 12 [ Mus musculus (house mouse) ]

    Gene ID: 56072, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lgals12provided by MGI
    Official Full Name
    lectin, galactose binding, soluble 12provided by MGI
    Primary source
    MGI:MGI:1929094
    See related
    Ensembl:ENSMUSG00000024972 AllianceGenome:MGI:1929094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Grip1; gal-12
    Summary
    Predicted to enable lactose binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway. Located in mitochondrion and nucleus. Orthologous to human LGALS12 (galectin 12). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 28.5), mammary gland adult (RPKM 22.2) and 8 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Lgals12 in Genome Data Viewer
    Location:
    19 A; 19 5.33 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (7574021..7584601, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (7596656..7607233, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene atlastin GTPase 3 Neighboring gene phospholipase A and acyltransferase 3 Neighboring gene STARR-seq mESC enhancer starr_45469 Neighboring gene STARR-seq mESC enhancer starr_45470 Neighboring gene phospholipase A and acyltransferase 5 Neighboring gene IscU iron-sulfur cluster scaffold homolog pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lactose binding  
    enables lactose binding PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in mitochondrion PubMed 
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    galectin-12
    Names
    galectin-related inhibitor of proliferation 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356574.2NP_001343503.1  galectin-12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC109225
      Consensus CDS
      CCDS29529.1
      UniProtKB/Swiss-Prot
      Q3UW90, Q8CCA4, Q8K2L7, Q91VD1, Q9JKX2
      Related
      ENSMUSP00000124610.2, ENSMUST00000159983.8
      Conserved Domains (2) summary
      smart00908
      Location:195313
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:26158
      Gal-bind_lectin; Galactoside-binding lectin
    2. NM_001370686.1NP_001357615.1  galectin-12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC109225
      Consensus CDS
      CCDS89332.1
      Related
      ENSMUSP00000078824.6, ENSMUST00000079902.6
      Conserved Domains (2) summary
      smart00908
      Location:182300
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:26158
      Gal-bind_lectin; Galactoside-binding lectin
    3. NM_019516.5NP_062389.1  galectin-12 isoform 1

      See identical proteins and their annotated locations for NP_062389.1

      Status: VALIDATED

      Source sequence(s)
      AC109225
      Consensus CDS
      CCDS29529.1
      UniProtKB/Swiss-Prot
      Q3UW90, Q8CCA4, Q8K2L7, Q91VD1, Q9JKX2
      Related
      ENSMUSP00000097318.4, ENSMUST00000099729.10
      Conserved Domains (2) summary
      smart00908
      Location:195313
      Gal-bind_lectin; Galactoside-binding lectin
      pfam00337
      Location:26158
      Gal-bind_lectin; Galactoside-binding lectin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      7574021..7584601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527221.5XP_006527284.1  galectin-12 isoform X1

      Conserved Domains (2) summary
      pfam00337
      Location:26158
      Gal-bind_lectin; Galactoside-binding lectin
      cl00071
      Location:195266
      GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...
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